Objective To analyze the value of iron metabolism related indexes in evaluating the condition and prognosis of lupus nephritis(LN).Methods This was a single-center,cross-sectional,observational cohort study in our hospital.The study time was from January 2021 to June 2022,and the subjects were 101 patients with systemic lupus erythematosus(SLE)and 11 healthy controls.Baseline urinary ferritin level and kidney injury molecule 1(KIM-1)protein level were compared between SLE patients and control group,and correlated with clinical features and subsequent treatment response.Results Compared with patients with active non-nephritis(ANR),patients with active lupus nephritis(ALN)were younger,with higher female ratio,proteinuria,rSLEDAI and SLEDAI and lower hemoglobin(P<0.05).The urinary ferritin level in ALN group was signifi-cantly higher than that in other groups[ALN 8.96(4.15,22.74)vs ANR 1.51(1.01,3.14),inactive SLE(INA)1.35(0.70,3.10)and healthy controls 1.07(0.55,1.42);H=43.57,P<0.05)].The urinary KIM-1 protein level in ALN group was significantly higher than that in ANR group and healthy controls[AlN 87.96(45.01,185.90)vs ANR 16.48(4.91,29.26),INA 9.62(3.13,57.55)and healthy controls 9.78(3.13,17.62);H=48.65,P<0.05)].Urinary ferritin and KIM-1 protein levels were positively correlated with proteinuria(correlation coefficient=0.385,0.538,both P<0.05).Compared with the group with treatment re-sponse,the levels of serum inosine,urinary ferritin and KIM-1 protein in the group without treatment response increased sig-nificantly(P<0.05).The AUC values of urinary ferritin and KIM-1 protein in predicting the therapeutic response of ALN were 0.815(95%CI:0.675-0.955)and 0.856(95%CI:0.731-0.981),respectively.Conclusion Urinary ferritin and KIM-1 protein may be a promising candidate biomarker for predicting the therapeutic response of LN.
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