The clinical value of serum amyloid A,white blood cell and C-reactive protein in preterm premature rupture of membranes complicated with chorioamnionitis
Objective To investigate the clinical value of serum amyloid A(SAA),white blood cell and C-reactive protein(CRP)in chorioamnionitis(CA)in preterm premature rupture of membranes(PPROM).Methods A total of 80 patients with premature rupture of membranes were selected from January 2020 to December 2021 in Zhuzhou Central Hospital.According to the results of placental disease after delivery,they were divided into chorioamniotic infection group(n=35 cases,including 18 cases in grade Ⅰ group,10 cases in grade Ⅱ group,7 cases in grade Ⅲ group)and non-chorioamniotic infection group(n=45 cases).Normal pregnant women were selected as control group(n=40 cases).The levels of serum amyloid A(SAA),white blood cells and C-reactive protein were measured in all pregnant women at admission.ROC curve was used to find the diagnostic value of each index in premature rupture of fetal membrane complicated with chorionic amniotitis.Results There was a positive correlation between SAA and white blood cell count and C-reactive protein in chorioamniotic infection group.The comparison of SAA level in the groups was as follows:Grade Ⅲ group>Grade Ⅱ group>Grade Ⅰ group.The values of SAA,leukocyte and C-reactive protein in chorioamniotic group were higher than those in non-chorioamniotic group and control group,and the non-chorioamniotic group was higher than control group.The cut-off values of various indexes in patients with preterm premature rupture of membranes combined with chorioamnitis were as follows:leukocyte13.28×109/L,C-reactive protein 14.28mg/L,se-rum amyloid A 13.46mg/L.The area under the curve of ROC of the three are 0.765,0.706 and 0.820 respectively,and the area under the curve of the three combined is 0.830.Conclusion SAA is in direct proportion to the severity of chorionic amniotitis.The diagnostic value of SAA in premature rupture of fetal membrane combined with chorionic amniotitis is better than that of leukocyte and C-reactive protein.
C-reactive proteinserum amyloid A proteinpremature rupture of membraneschorioamnionitis
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