Objective To analyze the effects of functional endoscopic sinus surgery(FESS)combined with dexamethasone nasal irrigation on clinical symptoms,inflammatory response,specific immunoglobulin E(sIgE)and eosinophils(EOS)in pa-tients with sinusitis.Methods A total of 150 patients with CRS in the hospital were enrolled as the research objects between October 2022 and October 2023.According to random number table method,they were divided into study group and control group,75 cases in each group.On basis of FESS,control group was given normal saline,while study group was given dexam-ethasone for nasal irrigation.The improvement of clinical symptoms,inflammatory response before and after treatment,and the effects on sIgE and EOS were compared between the two groups.Results After treatment,clinical control rate of study group was higher than that of control group(97.33%vs 89.33%,P<0.05).After treatment,scores of nasal congestion,head/facial pain,olfactory disturbance and runny nose were decreased in both groups,which were lower in study group than control group(P<0.05).After treatment,levels of IL-5,IL-6 and IL-12 were decreased in both groups,which were lower in study group than control group.After treatment,levels of sIgE and EOS were decreased in both groups,which were lower in study group than control group.The incidence of postoperative complications in study group was lower than that in control group(13.33%%vs 29.33%,but there was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Dex-amethasone nasal irrigation can improve clinical symptoms,effectively relieve inflammatory response,reduce sIgE,EOS and postoperative complications in patients with sinusitis after FESS.
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