摘要
目的：观察乌灵胶囊与阿普唑仑治疗2型糖尿病伴失眠症患者临床疗效。方法纳入2型糖尿病伴失眠症患者80例，分为研究组（口服乌灵胶囊）与对照组（口服阿普唑仑），每组各40例。采用匹兹堡睡眠质量指数（Pittsburgh sleep quality index ，PSQI）对服药前后患者睡眠情况进行评分。观察2组总有效率、不良反应率，观察服药期间患者空腹血糖（FBG）以及糖化血清白蛋白（Glycated albumin ，GA ）水平。结果研究组、对照组有效率分别为82.5％、80.0％，差异无统计学意义（ P＞0.05）。治疗后研究组睡眠质量、入睡时间、睡眠效率、催眠药物以及日间功能评分均明显低于对照组，差异有统计学意义（P＜0.05）。研究组FBG以及GA水平均低于对照组，差异有统计学意义（P＜0.05）。研究组不良反应率12.5％，对照组为55.0％，差异有统计学意义（ P＜0.05）。结论乌灵胶囊治疗2型糖尿病伴失眠症能够明显改善患者睡眠，一定程度上改善血糖水平，值得推广。
Abstract
Objective To analyze the curative effect of Wuling capsule and alprazolam in the treatment of type 2 diabetes complicated with insomnia.Methods 80 cases with insomnia and type 2 diabetes were divided into study group and control group ,each with 40 cases. Study group received Wuling capsule orally ,and the control group was given alprazolam orally. The quality of sleep before and after treatment was evaluated by Pittsburgh sleep quality index (PSQI) and the treatment efficiency and the rate of adverse reactions of two groups were observed. In addition ,fasting blood glucose (FBG) and serum glycated al‐bumin (GA) were detected.Results The treatment efficiency rate of study group and the control group were 82.5% and 80%(P>0.05). After treatment ,sleep quality ,onset time ,sleep efficiency and daytime function ,sleep medication scores and the levels of GA and FBG in study group were significantly lower than that in the control group(P<0.05). The adverse reaction rate was 12.5% in study group and 55% in control group ,with no statistical significance(P>0.05).Conclusion Wuling cap‐sule in the treatment of type 2 diabetes not only can improve the sleep in patients with insomnia but also improve blood sugar levels to a certain extent. It is worthy of promotion.
国家科技期刊平台
NSTL
维普
万方数据