Influence of sevoflurane combined with remifentanil maintenance anesthesia on recovery quality,cognitive and nerve injury in patients with interventional embolization of intracranial aneurysms
Influence of sevoflurane combined with remifentanil maintenance anesthesia on recovery quality,cognitive and nerve injury in patients with interventional embolization of intracranial aneurysms
Objective To observe the influence of maintenance anesthesia with sevoflurane combined with remifentanil on the recovery quality,cognitive function and nerve injury markers in patients undergoing interventional embolization of intracranial aneurysms.Methods The clinical data of 104 patients with interventional embolization of intracranial aneurysms in Yancheng NO.1 People's Hospital were retrospectively analyzed from August 2020 to August 2023.According to the different anesthesia methods,they were classified into conventional group(n=52)and sevoflurane combination group(n=52).The conventional group applied conventional anesthesia method,while the sevoflurane combination group applied sevoflurane combined with remifentanil to maintain anesthesia.The anesthesia effect,recovery quality(recovery time,anesthesia Steward recovery score,incidence rate of postoperative delirium),cognitive function(memory and execution scale(MES))and nerve injury markers(hypersensitive C-reactive protein(hs-CRP),neuron-specific enolase(NSE),myelin basic protein(MBP))were compared between the two groups.Results The MAP and HR in both groups at the time of skin incision,the time of embolus placement and 10-minute before the end of surgery reduced compared with those before anesthesia(P＜0.05),but there were no statistical differences between the two groups at the same time point(P＞0.05).The postoperative recovery time and incidence rate of post-operative delirium were shorter or lower in the sevoflurane combination group than those in the conventional group(P＜0.05),while the anesthesia Steward recovery score was higher than that in the conventional group(P＞0.05).At recovery,the MES score in the sevoflurane combination group was significantly higher compared with that in the conventional group(P＜0.05).There was no statistical significance on MES score between the two groups at 1-hour,6-hour and 12-hour of recovery(P＞0.05).At 1-day after surgery,the levels of serum hs-CRP,NSE and MBP in the sevoflurane combination group were lower compared to the conventional group(P＜0.05).Conclusion Sevoflurane combined with remifentanil maintenance anesthesia has a good anesthesia effect on patients with interventional embolization of intracranial aneurysms.It can effectively improve the recovery quality and reduce the influence of anesthetic drugs on cognitive function and nerve injury.
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