Objective To construct a four-level rehabilitation nursing program for severe neurosurgery patients and evaluate its application effect.Methods A total of 96 patients admitted to ICU of Neurosurgery Department of a Class Ⅲ Grade A Hospital in Beijing from August to December 2020 were selected as the experimental group.After the patient was admitted to ICU for ≥24 h and the condition was stable,the four-level rehabilitation nursing activity program was implemented according to the consciousness and muscle strength assessment of the patient.A total of 99 patients admitted to ICU of Neurosurgery Department from March to July 2020 were selected as the control group,and received routine rehabilitation nursing.The recovery status and complications of the two groups were compared.Results The duration of mechanical ventilation(11(5,17)d vs 16(7,24)d),length of stay in ICU(11(5,17)d vs 16(7,24)d),hospitalization cost(137 070(76 603,219 237)yuan vs 193 839(129 781,321 362)yuan)and APACHE-Ⅱ score of exit ICU((22.03±7.54)points vs(25.21±6.51)points)in experimental group were lower than those in control group(P<0.05),and ADL score of discharge(5(0,15)points vs 0(0,10)points)was higher than that in control group(P<0.05).There were statistically significant differences between the two groups in pulmonary infection(40(41.67%)vs 57(57.57%))and lower limb deep vein thrombosis(3(3.13%)vs 25(25.25%),P<0.05),but no significant differences in ICU delirium and stress injury(P>0.05).Conclusion Four-level rehabilitation nursing program for severe neurosurgery patients can improve the recovery of severe patients,reduce the incidence of complications,and contribute to the early recovery of severe patients.