中国实用神经疾病杂志2025,Vol.28Issue(1) :124-128.DOI:10.12083/SYSJ.231558

替罗非班在急性脑梗死静脉溶栓后患者中的应用进展

Application progress of tirofiban in patients with acute cerebral infarction after intravenous thrombolysis

陈英道 李育英 张岐平
中国实用神经疾病杂志2025,Vol.28Issue(1) :124-128.DOI:10.12083/SYSJ.231558

替罗非班在急性脑梗死静脉溶栓后患者中的应用进展

Application progress of tirofiban in patients with acute cerebral infarction after intravenous thrombolysis

陈英道 1李育英 1张岐平1
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作者信息

  • 1. 广西医科大学第七附属医院梧州市工人医院,广西梧州 543000
  • 折叠

摘要

急性脑梗死(ACI)静脉溶栓治疗后需继续接受抗血小板治疗,以预防梗死复发和其他心脑血管事件.替罗非班是较常用的抗血小板药物,在ACI患者中的应用愈加广泛,具有抗血小板聚集、抗炎等作用,能够减少血栓栓塞事件,且未增加出血风险.现阶段替罗非班在ACI静脉溶栓治疗后的应用已较为成熟,联合双抗血小板(DAPT)、肝素等药物均具有安全有效的优势,且低剂量的替罗非班安全性更高.以替罗非班为主的综合抗栓方案或可成为ACI静脉溶栓治疗后患者的优先选择.

Abstract

After intravenous thrombolysis therapy for acute cerebral infarction(ACI),it is necessary to continue receiving anti-platelet therapy to prevent infarction recurrence and other cardiovascular and cerebrovascular events.Tirofiban is a commonly used anti-platelet drug,which is more widely used in patients with ACI.It has anti-platelet aggregation,anti-inflammatory and other effects,can reduce thromboembolic events,and does not increase the risk of bleeding.At this stage,the application of tirofiban after intravenous thrombolytic therapy for ACI is relatively mature.No matter it is combined with double anti-platelet(DAPT),heparin and other drugs,it is safe and effective,and the safety of low dose tirofiban is higher.The comprehensive anti-thrombotic regimen based on tirofiban may be the first choice after intravenous thrombolytic treatment of ACI patient.

关键词

急性脑梗死/静脉溶栓/替罗非班/抗血小板聚集/抗炎

Key words

Acute cerebral infarction/Intravenous thrombolysis/Tirofiban/Anti-platelet aggregation/Anti-inflammatory

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出版年

2025
中国实用神经疾病杂志
郑州大学

中国实用神经疾病杂志

影响因子:1.136
ISSN:1673-5110
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