铁死亡的分子机制及其对膀胱癌的影响
Molecular mechanisms of ferroptosis and its effects on bladder cancer
李瑞杰 1宁艺萍 2袁亚成 3杨旭凯4
作者信息
- 1. 甘肃中医药大学第一临床医学院,兰州 730000;中国人民解放军联勤保障部队第九四〇医院泌尿外科,兰州 730050
- 2. 甘肃中医药大学第一临床医学院,兰州 730000
- 3. 甘肃省干细胞与基因药物重点实验室,兰州 730050
- 4. 中国人民解放军联勤保障部队第九四〇医院泌尿外科,兰州 730050
- 折叠
摘要
膀胱癌(bladder cancer,BC)是泌尿系统三大常见恶性肿瘤之一,具有发病率高、易转移、治疗效果不佳、预后较差的特点,严重威胁着全人类的健康.肿瘤细胞表现出强烈的需铁现象,而铁超载会诱导细胞发生铁死亡,即一种由脂质过氧化和细胞膜损伤引起的铁依赖性细胞死亡.因此,铁死亡具有很强的抗肿瘤潜力.铁死亡的分子机制与细胞磷脂代谢异常、铁代谢异常、抗氧化和非抗氧化系统Xc-/谷胱甘肽(glutathione,GSH)/谷胱甘肽过氧化物酶4(glutathione peroxidase 4,GPX4)的失调有关.铁死亡相关分子在BC的发生和发展、转移、耐药及免疫反应等方面发挥着重要的作用,有望成为治疗BC的靶点.
Abstract
Bladder cancer(BC)is one of the 3 common malignant tumors in the urinary system,with high incidence,easy metastasis,poor therapeutic efficacy,and poor prognosis,which seriously threatens the health of human.Tumor cells exhibit a strong demand for iron,and iron overload can induce ferroptosis,which is an iron dependent cell death caused by lipid peroxidation and cell membrane damage.Therefore,ferroptosis has strong anti-tumor potential.The molecular mechanisms of ferroptosis is associated with abnormalities in cellular phospholipid metabolism and iron metabolism,and dysregulation of antioxidant and non-antioxidant systems Xc-/glutathione(GSH)/glutathione peroxidase 4(GPX4).Ferroptosis relevant molecules play important roles in the occurrence and development,metastasis,drug resistance,and immune response of BC,and are expected to become targets for the treatment of BC.
关键词
膀胱癌/铁死亡/脂质过氧化/磷脂代谢/铁代谢/Xc-/谷胱甘肽/谷胱甘肽过氧化物酶4/铁死亡相关分子Key words
bladder cancer/ferroptosis/lipid peroxidation/phospholipid metabolism/iron metabolism/Xc-/glutathione/glutathione peroxidase 4/ferroptosis relevant molecules引用本文复制引用
基金项目
甘肃省自然科学基金(21JR11RA008)
兰州市人才创新创业项目(2021-RC-106)
出版年
2024
NETL
NSTL
维普
万方数据