首页|铁死亡的分子机制及其对膀胱癌的影响

铁死亡的分子机制及其对膀胱癌的影响

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膀胱癌(bladder cancer,BC)是泌尿系统三大常见恶性肿瘤之一,具有发病率高、易转移、治疗效果不佳、预后较差的特点,严重威胁着全人类的健康.肿瘤细胞表现出强烈的需铁现象,而铁超载会诱导细胞发生铁死亡,即一种由脂质过氧化和细胞膜损伤引起的铁依赖性细胞死亡.因此,铁死亡具有很强的抗肿瘤潜力.铁死亡的分子机制与细胞磷脂代谢异常、铁代谢异常、抗氧化和非抗氧化系统Xc-/谷胱甘肽(glutathione,GSH)/谷胱甘肽过氧化物酶4(glutathione peroxidase 4,GPX4)的失调有关.铁死亡相关分子在BC的发生和发展、转移、耐药及免疫反应等方面发挥着重要的作用,有望成为治疗BC的靶点.
Molecular mechanisms of ferroptosis and its effects on bladder cancer
Bladder cancer(BC)is one of the 3 common malignant tumors in the urinary system,with high incidence,easy metastasis,poor therapeutic efficacy,and poor prognosis,which seriously threatens the health of human.Tumor cells exhibit a strong demand for iron,and iron overload can induce ferroptosis,which is an iron dependent cell death caused by lipid peroxidation and cell membrane damage.Therefore,ferroptosis has strong anti-tumor potential.The molecular mechanisms of ferroptosis is associated with abnormalities in cellular phospholipid metabolism and iron metabolism,and dysregulation of antioxidant and non-antioxidant systems Xc-/glutathione(GSH)/glutathione peroxidase 4(GPX4).Ferroptosis relevant molecules play important roles in the occurrence and development,metastasis,drug resistance,and immune response of BC,and are expected to become targets for the treatment of BC.

bladder cancerferroptosislipid peroxidationphospholipid metabolismiron metabolismXc-/glutathione/glutathione peroxidase 4ferroptosis relevant molecules

李瑞杰、宁艺萍、袁亚成、杨旭凯

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甘肃中医药大学第一临床医学院,兰州 730000

中国人民解放军联勤保障部队第九四〇医院泌尿外科,兰州 730050

甘肃省干细胞与基因药物重点实验室,兰州 730050

膀胱癌 铁死亡 脂质过氧化 磷脂代谢 铁代谢 Xc-/谷胱甘肽/谷胱甘肽过氧化物酶4 铁死亡相关分子

甘肃省自然科学基金兰州市人才创新创业项目

21JR11RA0082021-RC-106

2024

10.11817/j.issn.1672-7347.2024.230352

中南大学学报(医学版)
中南大学

中南大学学报(医学版)

CSTPCD北大核心
影响因子：1.459
ISSN：1672-7347
年,卷(期)：2024.49(2)
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