癌症治疗中新型抗体偶联药物的研究进展
Research progress on novel antibody drug conjugates in cancer therapy
李雨凝 1苏佳琳 1谭树华 2罗永忠 3张乐蒙3
作者信息
- 1. 湖南省肿瘤医院胸部内一科,长沙 410013;湖南科技大学生命科学与健康学院,湖南 湘潭 411201
- 2. 湖南科技大学生命科学与健康学院,湖南 湘潭 411201
- 3. 湖南省肿瘤医院胸部内一科,长沙 410013
- 折叠
摘要
传统抗体偶联药物(antibody drug conjugates,ADC)通过将单克隆抗体与细胞毒性药物相结合,实现对癌细胞的精准打击,但在稳定性、靶向性、疗效及安全性等方面依然存在诸多不足.新型ADC,如双特异性、位点特异性、双有效载荷和前药型ADC,通过同时结合2个不同抗原或表位、选择更稳定的连接子、与抗体特定氨基酸位点偶联、携带不同药物有效载荷以及采用前药策略等优化方法,在保留传统ADC作用特点的基础上,显著提高药物的稳定性、靶向性、疗效和安全性,能更好地满足临床治疗的需求.新型ADC可能会在未来的癌症治疗中发挥重要的作用.探讨新型ADC在癌症治疗中的进展并分析其优势与挑战,可为开发抗癌策略提供理论支持,为药物研发提供方向.
Abstract
Traditional antibody drug conjugates(ADC)combine monoclonal antibodies with cytotoxic drugs to accurately strike cancer cells,but there are still many shortcomings in stability,targeting,efficacy,and safety.Novel ADC,such as bi-specific,site-specific,dual-payload,and pro-drug type ADC,can be optimized by simultaneously binding 2 different antigens or epitopes,selecting more stable linkers,coupling with specific amino acid sites of antibodies,carrying different drug payloads,and adopting prodrug strategies,while retaining the characteristics of traditional ADC.Significantly improving the stability,targeting,efficacy and safety of drugs can better meet the needs of clinical treatment.Novel ADC will play a more important role in cancer treatment in the future.Discussing the progress of novel ADC in cancer treatment and analyzing their advantages and challenges can provide theoretical support for the development of anti-cancer strategies and provide directions for drug research and development.
关键词
抗体偶联药物/癌症/双特异性/位点特异性/双有效载荷/前药型Key words
antibody drug conjugates/cancer/bi-specific/site-specific/dual payload/pro-drug type引用本文复制引用
基金项目
湖南省自然科学基金(2023JJ60039)
出版年
2024
NETL
NSTL
维普
万方数据