首页|Epstein-Barr病毒相关淋巴上皮瘤样肝内胆管癌3例并文献复习

Epstein-Barr病毒相关淋巴上皮瘤样肝内胆管癌3例并文献复习

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肝淋巴上皮瘤样癌(Lymphoepithelioma-like carcinoma,LELC)是一种极其罕见的恶性肿瘤,其特点是未分化的恶性上皮细胞及明显的淋巴浸润.肝LELC主要包括淋巴上皮瘤样肝细胞癌(lymphoepithelioma-like hepatocellular carcinoma,LEL-HCC)和 淋 巴 上 皮 瘤 样 肝 内 胆 管 癌(lymphoepithelioma-like intrahepatic cholangiocarcinoma,LEL-CC).EB病毒(Epstein-Barr virus,EBV)感染被认为是LELC癌变的重要因素.中南大学湘雅医院自2005年以来共收治3例EBV相关LEL-CC患者,CT均提示肝脏肿块,经手术切除后,3例患者EBV编码的RNA(EBV-encoded RNA,EBER)和CK19表达均为阳性,病理学证实为EBV相关的LEL-CC.2例患者术后预后良好,1例患者术后接受相关免疫治疗及化学治疗.结合现有文献分析,笔者认为可将肝LELC纳入肝肿瘤的分类,这将为肝LELC的精准诊断及治疗提供新思路.
Epstein-Barr virus-associated lymphoepithelioma-like intrahepatic cholangiocarcinoma:A report of 3 cases and literature review
Hepatic lymphoepithelioma-like carcinoma(LELC)is an extremely rare malignant tumor characterized by undifferentiated malignant epithelial cells and significant lymphatic infiltration.Hepatic LELC mainly includes lymphoepithelioma-like hepatocellular carcinoma(LEL-HCC)and lymphoepithelioma-like intrahepatic cholangiocarcinoma(LEL-CC).Epstein-Barr virus(EBV)infection is considered as an important factor in LELC carcinogenesis.Since 2005,Xiangya Hospital of Central South University has treated a total of 3 patients with EBV-associated LEL-CC,which all showed liver masses by CT scans.After surgical resection,the EBV encoded RNA(EBER)and CK19 expression in all 3 patients were positive,and pathological examination confirmed EBV-associated LEL-CC.Two patients had a good postoperative prognosis,while 1 patient received relevant immunotherapy and chemotherapy after surgery.Based on the analysis of existing literature,the author believes that hepatic LELC can be included in the classification of liver tumors,which will provide new ideas for the accurate diagnosis and treatment of hepatic LELC.

lymphoepithelioma-like carcinomalymphoepithelioma like intrahepatic cholangiocarcinomahepatocellular carcinomaEpstein-Barr virus

彭璐珊、彭先楚、段赛丽、张哲嘉

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中南大学湘雅医院病理科,长沙 410008

中南大学基础医学院细胞与分子生物学实验室,长沙 410013

中南大学湘雅医院普通外科,长沙 410008

淋巴上皮瘤样癌 淋巴上皮瘤样肝内胆管癌 肝细胞癌 EB病毒

Hunan Provincial Innovation Foundation for Postgraduate,China

CX20230328

2024

10.11817/j.issn.1672-7347.2024.230298

中南大学学报(医学版)
中南大学

中南大学学报(医学版)

CSTPCD北大核心
影响因子：1.459
ISSN：1672-7347
年,卷(期)：2024.49(2)
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