摘要
红细胞是人体内血液运输氧气最主要的媒介,其功能主要是由血红蛋白(hemoglobin,Hb)的构象变化实现的.Hb是由4个亚单位组成的四聚体,HbA是健康成人中主要的Hb,以紧张态(T态)和松弛态(R态)2种形式存在.Hb构象的内源性调节器包括2,3-双磷酸甘油酸、二氧化碳、质子和氯化物等,外源性调节器包括肌醇六磷酸、肌醇三焦磷酸、苯扎贝特、尿素衍生物L35、香兰素等,其作用机制各不相同.Hb构象调节剂的应用为研究缺氧供氧问题和治疗镰状细胞病提供了新的思路.
Abstract
Red blood cells(RBCs)are the primary mediators of oxygen transport in the human body,and their function is mainly achieved through conformational changes of hemoglobin(Hb).Hb is a tetramer composed of four subunits,with HbA being the predominant Hb in healthy adults,existing in two forms:tense state(T state)and relaxed state(R state).Endogenous regulators of Hb conformation include 2,3-diphosphoglyceric acid,carbon dioxide,protons,and chloride ions,while exogenous regulators include inositol hexaphosphate,inositol tripyrophosphate,benzabate,urea derivative L35,and vanillin,each with different mechanisms of action.The application of Hb conformational regulators provides new insights into the study of hypoxia oxygen supply issues and the treatment of sickle cell disease.
基金项目
国家自然科学基金(82173738)
医院科研计划立项项目(2021yxky005)
医学科技青年培育计划拔尖项目(20QNPY070)
维普
万方数据