红景天苷通过miRNA-mRNA信号轴抑制肿瘤的机制
Mechanism of salidroside in tumor suppression through the miRNA-mRNA signaling axis
吴枭雄 1张振东 1王小平1
作者信息
- 1. 高原低氧环境与生命健康实验室,西藏藏医药研究中心藏药活性成分及药理机制研究联合实验室,西藏民族大学医学院,陕西咸阳 712082
- 折叠
摘要
随着中医药的快速发展和红景天苷(salidroside,sal)的多种抗癌效应不断被发现,已经sal可通过诱导细胞凋亡和自噬,调节细胞周期和肿瘤微环境,调控癌症相关信号通路及信号分子等来抑制肿瘤增殖、侵袭和迁移.微RNA(microRNA,miRNA)-mRNA信号轴也可通过改变miRNA的表达来调控靶mRNA的表达,从而影响癌细胞的生长周期、增殖、代谢等.研究表明sal可以通过调控miRNA-mRNA信号轴影响多种恶性肿瘤的发生和发展,如抑制肺癌、胃癌和鼻咽癌等的进展,且sal抑癌时具有明显的时间及剂量依赖性.总结近年来sal调控miRNA-mRNA信号轴抑制肿瘤的具体机制,可为肿瘤的防治研究提供新的理论依据、诊断和治疗思路.
Abstract
With the rapid development of traditional Chinese medicine and the continuous discovery of various anticancer effects of salidroside(sal),it is known that sal inhibits tumor proliferation,invasion and migration by inducing apoptosis and autophagy,regulating the cell cycle,modulating the tumor microenvironment,and controlling cancer-related signaling pathways and molecules.The microRNA(miRNA)-mRNA signaling axis can regulate the expression of target mRNAs by altering miRNA expression,thereby affecting the growth cycle,proliferation,and metabolism of cancer cells.Studies have shown that sal can influence the occurrence and progression of various malignant tumors through the miRNA-mRNA signaling axis,inhibiting the progression of lung cancer,gastric cancer,and nasopharyngeal carcinoma,with a notable time and dose dependence in its antitumor effects.Summarizing the specific mechanism of sal regulating miRNA-mRNA signaling axis to inhibit tumors in recent years can provide a new theoretical basis,diagnosis,and therapeutic methods for the research on prevention and treatment of tumors.
关键词
肿瘤/红景天苷/微RNA/mRNA/信号通路Key words
tumor/salidroside/microRNA/mRNA/signaling pathway引用本文复制引用
基金项目
西藏自治区自然科学基金(XZ202101ZR0074G)
陕西省自然科学基金(2020JM-590)
陕西省自然科学基金(2022JM-465)
教育部春晖计划科研项目(202070310)
出版年
2024
NETL
NSTL
万方数据