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再生性牙髓治疗的研究进展

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牙髓作为牙体结构中唯一的软组织结构,具有感觉、营养等诸多功能,但牙髓本身却极易受到外界因素影响而坏死.目前针对牙髓坏死最常用的治疗办法是根管治疗术,但根管治疗后的牙齿容易发生二次感染,出现牙根纵裂等不良预后.再生性牙髓治疗旨在替换受损牙齿结构的生物程序,包括牙本质、牙根结构以及牙髓-牙本质复合体的细胞,展现出了解决临床症状、实现牙根甚至牙髓再生等巨大优势.在牙髓干细胞被发现后,再生性牙髓治疗又展现出了新的活力,细胞移植、细胞归巢等治疗方案发展迅速并展现出广阔的应用前景.
Research progress of dental pulp regeneration treatment
The dental pulp is the only soft tissue structure within the tooth,serving functions such as sensation and nutrition.However,the dental pulp is highly susceptible to necrosis due to external factors.Currently,root canal therapy is the most commonly used treatment for pulp necrosis.Nevertheless,teeth treated with root canal therapy are prone to secondary infections and adverse outcomes like vertical root fractures.Regenerative endodontic therapy has emerged as a solution,aiming to replace damaged tooth structures,including dentin,root structure,and the pulp-dentin complex cells.This approach demonstrates significant advantages in addressing clinical symptoms and achieving regeneration of the root and even the pulp.Since the discovery of dental pulp stem cells,regenerative endodontic therapy has gained new momentum.Advances in cell transplantation and cell homing techniques have rapidly developed,showing promising potential for clinical applications.

regenerative endodontics therapydental pulp stem cellsdental pulp regenerationcell homing

罗智伟、于明楷、申婷

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中南大学湘雅口腔医院牙体牙髓科,长沙 410008

湖南省口腔重大疾病与口腔健康临床医学研究中心,长沙 410008

再生性牙髓治疗 牙髓干细胞 牙髓再生 细胞归巢

国家自然科学基金湖南省自然科学基金

820711292020JJ5406

2024

中南大学学报(医学版)
中南大学

中南大学学报(医学版)

CSTPCD北大核心
影响因子:1.459
ISSN:1672-7347
年,卷(期):2024.49(6)
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