Ferroptosis is a unique form of cell death driven by iron-dependent lipid peroxidation,with regulatory mechanisms involving metabolic dysregulation and imbalance in redox systems.Ferroptosis is closely related to various immune cells in the tumor immune microenvironment,including both anti-tumor and pro-tumor immune cells,and it demonstrates significant potential in tumor immunotherapy.A systematic review of the regulatory mechanisms of ferroptosis and its relationship with immune cells can provide deeper insights into its application prospects in tumor immunotherapy.