首页|Optimization of extraction technology of safflower polysaccharide based on central composite design-response surface methodology

Optimization of extraction technology of safflower polysaccharide based on central composite design-response surface methodology

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Objective: To explore the best extraction technology of safflower polysaccharide by central composite design response surface methodology and evaluate its quality. Methods: Taking the extraction rate of Carthamus tinctorius polysaccharide as the index, taking the ratio of solid to liquid, extraction time, extraction temperature and extraction times as the investigation factors, based on the single factor experiment, the central composite design-response surface methodology was used to optimize the optimum extraction process of Carthamus tinctorius polysaccharide and verify it. Results: The response surface model was established with the extraction rate of Carthamus tinctorius polysaccharide as dependent variable Y, the ratio of solid to liquid, extraction time and extraction temperature as independent variables X, P<0.0001. The optimum extraction process was as follows: the ratio of solid to liquid was 1: 16.69, the extraction temperature was 91.39℃, and the extraction working time was 89.78min. Under these conditions, the extraction rate of safflower polysaccharide can reach 7.45％, The experimental results show that RSD is 1.05％,and the model can well predict the experimental results. Conclusion: Central Composite Design-Response Surface Methodology has the advantages of high extraction rate, simple, effective and reasonable process operation, high stability and high precision, which can be fully applied to the resource management and utilization of safflower polysaccharide.

Safflower polysaccharideCentral composite designExtraction processExtraction percentage

Rui Wang、Ya-Lan Li、Hao-Tian Bai、Jing Yang

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School of Pharmacy,Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China

Basic Medical College of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China

国家自然科学基金General Program of Natural Science Foundation of HeilongjiangProject of Excellent Youth Talents of Heilongjiang

81603418H2014722020YQ05

2022

海南医科大学学报(英文版)

海南医科大学学报(英文版)

ISSN：
年,卷(期)：2022.28(5)
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