首页|Significance of preoperative fibrinogen levels, neutrophils-to-lymphocyte ratio and its combined scores in evaluating the prognosis of postoperative patients with gastric cancer

Significance of preoperative fibrinogen levels, neutrophils-to-lymphocyte ratio and its combined scores in evaluating the prognosis of postoperative patients with gastric cancer

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Objective:To investigate the clinic significance of the combined detection of peripheral fibrinogen (Fbg) and neutrophils-to-lymphocyte ratio (NLR) (F-NLR) on the prognosis of postoperative gastric cancer patients. Methods: The clinical and pathological characteristics of 70 gastric cancer patients who were diagnosed by gastroscopy and surgically resected were collected, and the relationship between Fbg, NLR and F-NLR scores and pathological characteristics and prognosis of gastric cancer patients was retrospectively analyzed. Results: There were statistically significant differences in the levels of NLR in gastric cancer patients of different genders (P < 0.05), while there were no significant differences in the levels of NLR and Fbg in other pathological factors such as age, T stage, lymph node metastasis and TNM stage(P > 0.05). The f-NLR score of gastric cancer patients with different gender, T stage and TNM stage had statistical significance (P < 0.05), but there was no statistical significance in the F-NLR score of gastric cancer patients with different age and whether lymph node metastasis (P > 0.05). Univariate analysis showed that Fbg, NLR, F-NLR score, and TNM stage had an effect on recurrence and survival of patients with gastric cancer after surgery (P <0.05); multivariate COX regression analysis showed that only F-NLR score and TNM stage were independent risk factors for relapse and survival of patients with gastric cancer (P <0.05). Conclusion: The F-NLR scores about the combined detection of Fbg and NLR may guide clinical prediction of the prognosis of gastric cancer patients.

FibrinogenNeutrophils-to-lymphocyte ratioF-NLRGastric cancerPrognosis

Jian-Zhong Deng、Xiu-Ling Liu、Qian Liu、Wen-Jing Li、Wen-Bin Lu

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Department of Oncology,Wujin Hospital Affiliated to Jiangsu University,Wujin Clinical College of Xuzhou Medical University,Changzhou 213017,China

General Project of National Natural Science Foundation of ChinaHighlevel Health Talent Project of Jiangsu Provincial Health CommissionWujin District Science and Technology PlanDevelopment Project

81872275LGY2018017WS201702

2022

海南医科大学学报(英文版)

海南医科大学学报(英文版)

ISSN：
年,卷(期)：2022.28(5)
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