首页|Meta-analysis of effectiveness and safety of Chinese herbal medicine treatment for obese patients
Meta-analysis of effectiveness and safety of Chinese herbal medicine treatment for obese patients
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Objective: To systematically review the efficacy and safety of traditional Chinese medicine for weight loss. Methods: We used standard methodologies to search, review, analyse and synthesize published data on the efficacy, safety. Search randomized controlled trial(RCT) from CNKI、WanFang Data,VIP Data, Sinomed,The Cochrane Library,Pubmed,MEDLINE and Web of Scinece.Two reviewers independently screened literature,extracted data and assessed the risk of bias of included trials according to the Cochrane handbook. Then use review manager5.3 completed meta-analysis. Results: A total of 16 RCT were included.The results of meta-analysis showed that compared with placebo or other anti-obesity medicine, CHM is effective and safe in reducing theweight[MD=-1.99,95％CI(-2.94,-1.02),p<0.0001], BMI[MD=-0.78,95％CI(-1.02,-0.54), p<0.00001],waist circumference[MD=-2.71,95％CI(-3.81,-1.59), p<0.00001],fat mass[MD=-1.23,95％CI(-2.37,-0.18), p=0.02],fat mass percentage [MD=-2.71,95％CI(-3.81-1.59), p<0.00001] of patients.There were no significant changes in glucose and lipid metabolism. 6 RCTs reported adverse events (gastrointestinal reactions and headaches), 18 cases (1.40％) in the treatment group and 7 cases (0.54％) in the control group; no serious adverse reactions were seen. Conclusion:Chinese herbal medicine has define effect and safety, but that is uncertain about inregulating the glucose and lipid metabolism, and more high-quality literature is needed for further verification.
Zhen-Xiu Liu、Jun-Rui Guo、Xin Jin、Xiao-Tian Zhang、Feng Tao
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Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China
Shanghai Hospital of Traditional Chinese Medicine,Shanghai University of TCM,Shanghai 200071,China
National Ministry of Science and Technology's Key Research and Development Program"Active Health and Aging Technology Response"SShanghai Shenkang Hospital Development Center ClinicalTechnology Innovation ProjectNational Natural Science Foundation of ChinaShanghai Science and Technology Commission Traditional Chinese Medicine Bootstrap Project
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