首页|Effect of Xifeng Capsule on blood stasis in patients with rheumatoid arthritis by regulating miR-126-VEGF/PI3K/AKT signaling pathway
Effect of Xifeng Capsule on blood stasis in patients with rheumatoid arthritis by regulating miR-126-VEGF/PI3K/AKT signaling pathway
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Objective: From the perspective of miR-126-vascular endothelial cytokine (VEGF)/phosphatidylinositol 3-kinase (PI3K)/ser-threonine protein kinase (AKT) signaling pathway, Xinfeng Capsule (XFC) can improve rheumatoid arthritis (RA) ) The mechanism of the patient's blood stasis state. Methods: Sixty RA patients meeting the diagnostic criteria were selected and divided into XFC treatment group 30 cases and Leflunomide (LEF) control group 30 cases according to the random number table method. The treatment group took Xinfeng Capsules (3 capsules each time, 3 times/d), and the control group took Leflunomide (1 capsule each time, 1 times/d). Observe the blood stasis symptom scores of RA patients, and detect the laboratory indicators erythrocyte sedimentation rate (ESR), c-reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated peptide antibody (CCP), thrombin time (TT), part prothrombin time (APTT), prothrombin time (PT), D dimer (DD), fibrinogen (FBG), platelets (PLT), mean platelet volume (MPV), platelet distribution width (PDW) levels. Real-time fluorescent quantitative PCR method was used to detect the level of miR-126, and the ELISA method was used to detect the levels of tumor necrosis factor (TNF-α), interleukin-6 (IL-6), IL-35, VEGF, PI3K, and AKT. Spearman method was used to analyze the correlation between the total score of blood stasis symptoms, blood stasis-related indicators and disease activity indicators, cytokines, miR-126, VEGF, PI3K, and AKT in RA patients. Results: Comparing the two groups after treatment, the XFC group improved blood stasis symptoms, disease activity indicators, decreased miR-126, VEGF, PI3K, AKT, TNF-α, IL-6, D-D, FBG, PLT, and increased IL-35 The level was significantly better than the LEF group, with statistical significance (P<0.05, P<0.01). Correlation analysis showed that there was a certain correlation between the total score of blood stasis symptoms, blood stasis related indicators and disease activity indicators, cytokines, miR-126, VEGF, PI3K, and AKT in RA patients. Conclusion: There is blood stasis in RA patients. XFC may improve the cytokine network disorder of patients through miR-126-VEGF/PI3K/AKT signaling pathway, thereby improving the blood stasis status of RA patients.
Zhang-Ying Lin、Yuan Wang、Chuan-Bing Huang、Wan-Dong Zhang、Gui-Zhen Wang、Rui-Lian Chen、Xue Gong
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Graduate School of Anhui University of Chinese Medicine,Hefei 230038,China
Department of Rheumatology,the First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,China
Xin'an Medical Education Ministry Key Laboratory Open Fund ProjectAnhui Natural Science Youth FundAnhui Province University Outstanding Young Talent Support ProgramAnhui Province Key Laboratory Construction ProjectConstruction Project of Liu Jian StudioA Famous Chinese Medicine Doctor in Anhui Province12th Batch of"115"Innovation Team Project in Anhui Province
NETL
NSTL
万方数据
维普
