首页|Meta-analysis of efficacy and safety of Endostar combined with vinorelbine and cisplatin in the treatment of non-small cell lung cancer
Meta-analysis of efficacy and safety of Endostar combined with vinorelbine and cisplatin in the treatment of non-small cell lung cancer
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NETL
NSTL
维普
万方数据
Objective: To systematically evaluate the efficacy and safety of rh-endostain(YH-16,Endostar) combined with vinorelbine and cisplatin (NP regimen) in the treatment of non-small cell lung cancer(NSCLC),and to provide evidence-based reference for clinical drug use. Methods: Retrieved from PubMed, EMBASE, the Cochrane Library, Clinical Trials, CNKI, VIP and Wan Fang database, randomized controlled trials(RCT)about YH-16 combined with NP regimen(NPY regimen, trial group) vs. NP regimen(control group)for NSCLC were collected. After screening the literature and extracting the data, the two persons evaluated the quality of the included studies, and used Rev Man 5.3 software to merge effect size. Results: A total of 18 articles were included, with a total of 2051 patients. Results of Meta-analysis showed that response rate [RR=1.66,95％CI(1.44,1.91),P<0.00001]、 clinical benefit rate [RR=1.21,95％CI(1.14,1.29),P<0.00001] and quality of life improvement rate [RR=3.42,95％CI(2.45, 4.79),P<0.00001] of trial group were significantly higher than those of control group. Besides, the serum CEA level [MD=-4.78,95％CI(-7.11,-2.46),P<0.0001] and CA125 level [MD=-16.44,95％CI(-20.83,-12.05),P<0.00001] of trial group were significantly lower than that of control group. There was no statistical significance in the 1-year survival rate and the incidence of myelosuppression, cardiotoxicity, gastrointestinal reaction, damage to the kidneys and liver, and alopecia (P>0.05). Conclusion: Compared with NP regimen alone, NPY regimen can improve the efficacy and quality of life of NSCLC patients, reduce the level of tumor markers, and does not increase the occurrence of adverse reactions, and has good efficacy and safety. However, the existing evidence shows that NPY regimen has the same effect as NP regimen alone in improving the 1-year survival rate of patients. The above conclusions need to be confirmed by further studies.
NETL
NSTL
维普
万方数据
