首页|The relationship between Metrnl and diabetic cardiomyopathy and its related molecular mechanism

The relationship between Metrnl and diabetic cardiomyopathy and its related molecular mechanism

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Objective: To investigate the changes of serum concentration of Metrnl in diabetic cardiomyopathy mice, and the relationship between Metrnl and Diabetic cardiomyopathy(DCM) and its molecular mechanism.Methods: Fifteen male mice were randomly divided into experimental group(DCM+Metrnl),model group(DCM)and control group.Metrnl concentration was measured with an enzyme-linked immunosorbent assay.The experimental group was treated with Metrnl,and the control group and model group were treated with equal volume solvent.Then the myocardial pathological changes,reactive oxygen species and the expression of PPARs and GLUT4 protein and the expression of CD36 and SOD gene were observed after 7 days of administration of recombinant Metrnl.Results: Serum Metrnl concentrations were elevated in DCM(P>0.05).Metrnl reduced the serum concentrations of total cholesterol(TG,P<0.05),triglyceride(TC,P<0.05)and low density lipoprotein cholesterol(LDL-C,P<0.05),while increased high density lipoprotein cholesterol(HDL-C,P<0.05)in DCM.In addition,Metrnl improved the energy metabolism of DCM,decreased the production of reactive oxygen species(ROS)and up-regulated the protein expressions of PPAR-a,PPAR-β/ ,GLUT4 and the expression of SOD in cardiomyocytes,while CD36 gene expression was down-regulated.Conclusion: Serum Metrnl concentrations were elevated in DCM mouse modles.Metrnl improved lipid metabolism and cardiac function in DCM. Besides,it can reduced myocardial oxidative stress injury through PPAR-β/ ,GLUT4 pathway.

Diabetic cardiomyopathyMetrnlPPARsGLUT4ROSOxidative stress injury

Min Zhang、Rui-Lin Ding、Feng Jiang、Qing Peng、Xiao-Jie Wang

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Department of Cardiovascular Medicine

GCP

Department of Endocrinology,Affiliated Hospital of Southwest Medical University,Luzhou 646000,China

Scientific Research Fund Project of Science and Technology Department of Sichuan ProvinceScience Foundation of the Sichuan Medical Association Shihuida ProjectDoctoral Research Foundation of the Affiliated Hospital of Southwest Medical University

[2012]62012JY00682016SHD0122018099

2022

海南医科大学学报(英文版)

海南医科大学学报(英文版)

ISSN：
年,卷(期)：2022.28(9)
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