Analysis of the mechanism of Radix Astragali-Radix Pseudostellariae in the treatment of chronic heart failure based on network pharmacology

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外文摘要：Objective: To explore and analyze the effective component, target and mechanism of action of Radix Astragali-Radix Pseudostellariae in the treatment of chronic heart failure (CHF) by network pharmacological research methods. Methods: With the help of TCMSP database, the effective chemical constituents and targets of Radix Astragali-Radix Pseudostellariae were screened out, and CHF-related proteins were obtained by Gene Cards and OMIM database. The target protein interaction network (PPI) was constructed on the String database platform, and using DAVID database to conduct the GO function and KEGG pathway enrichment analysis on the target of the obtained astragalus-pseudostellariae for the treatment of CHF. Results: Radix Astragali-Radix Pseudostellariae were selected as 28 effective chemical components and 104 therapeutic targets for CHF. There were obtained 49 GO functional annotations and 86 KEGG signaling pathways. Conclusion: Radix Astragali-Radix Pseudostellariae can treat CHF through multi-target and multi-pathway.

外文关键词：

Radix Astragali-Radix PseudostellariaeChronic heart failureNetwork pharmacologyTargetsMechanism of action

作者：

Mei-Hui Chen、Yu-Bo Han、Yan-Bo Sui、Li Liu

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作者单位：

Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China

The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China

基金：

Youth Science Fund Project of National Natural Science Foundation of ChinaScientific Research Fund of Heilongjiang University of Traditional Chinese Medicine

项目编号：

819041072019TD01

出版年：

2022

海南医科大学学报(英文版)

ISSN：

年,卷(期)：2022.28(9)

参考文献量9