首页|Mechanism of action and targeted therapy of stellate cells in liver fibrosis

Mechanism of action and targeted therapy of stellate cells in liver fibrosis

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The incidence of liver fibrosis is increasing worldwide, and if left untreated, it will later develop into cirrhosis with a high mortality rate. In this paper, the activation pathway and related mechanism of stellate cells in liver fibrosis are introduced, and some current therapeutic methods are summarized. These results suggest that stellate cells play an important role in liver fibrosis, and targeted therapy for the purpose of inhibiting the activation of stellate cells and inducing their apoptosis is expected to be an effective regimen to reverse liver fibrosis. However, there are some problems such as insufficient in-depth study of related mechanisms and imperfect experiments. In future animal experiments and clinical trials, more studies can be carried out to provide high-quality protocols for the treatment of liver fibrosis.

Hepatic fibrosisHepatic stellate cellCell activationTherapy

Sheng-Lan Zeng、Rong-Zhen Zhang、Na Wang、Ting-Shuai Wang、Cong Wu、Xiao-Bin Qin、De-Wen Mao

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The First Clinical Faculty of Guangxi University of Chinese Medicine,Nanning 530022,China

The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530022,China

国家自然科学基金面上项目国家自然科学基金面上项目

8177423681960841

2022

海南医科大学学报(英文版)

海南医科大学学报(英文版)

ISSN:
年,卷(期):2022.28(9)
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