Correlation study between dendritic cell and eosinophil in refractory rhinosinusitis

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外文摘要：Objective: To investigate the correlation of refractory rhinosinusitis by detecting the expression of dendritic cells and eosinophils infiltration in nasal mucosa. Methods: Histological staining was performed to detect eosinophils infiltration respectively in 30 normal nasal mucosa, 30 chronic rhinosinusitis tissues and 30 refractory rhinosinusitis tissues,Immunohistochemistry and immunofluorescence double labeling were performed to detect the expression of CD83 and CD11c in each group, and univariate anova was used to analyze the differences among groups.The correlation between the co-expression of CD83 and CD11c and the infiltration of eosinophilic cells was measured by Pearson correlation analysis. Results: The positive expression of dendritic cells immune markers CD83 and CD11c and eosinophils infiltration of refractory rhinosinusitis was significantly increased compared with the other two groups (P <0.05). Through Pearson correlation analysisthe, correlation coefficient r between CD83 and CD11c co-expression and eosinophils infiltration in each group was positive and P <0.05, both were positively correlated. Conclusion: The number of dendritic cells in refractory rhinosinusitis increased significantly and was positively correlated with the infiltration of eosinophils, which was involved in the development of refractory rhinosinusitis.

外文关键词：

Refractory rhinosinusitisEosinophilDendritic cell

作者：

Yin-Ping Zeng、Zhong-Lin Mu、Shun Ding、Zhi-Fei Luo

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作者单位：

First Affiliated Hospital of Hainan Medical University

Department of Otorhinolaryngology Head and Neck Surgery

基金：

Youth Cultivation Fund Project of the First Affiliated Hospital of Hainan Medical College国家自然科学基金High Level Talents Project of Hainan Natural Science Foundation

项目编号：

HYFYPY20181581660171820RC627

出版年：

2022

海南医科大学学报(英文版)

ISSN：

年,卷(期)：2022.28(11)

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