首页|Effectiveness of Shengmai Injection on angina pectoris based on real-world propensity score method

Effectiveness of Shengmai Injection on angina pectoris based on real-world propensity score method

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Objective: Shengmai injection is a commonly used traditional Chinese medicine for the treatment of angina pectoris. However, there is still a lack of high-quality clinical research evidence for the treatment effect of Shengmai injection for angina pectoris. Real-world studies based on large samples can provide Shengmai injection. Researches on the treatment of angina pectoris with Shengmai injection provide important evidence. Methods: This article is based on the information collected by the hospital information system (HIS) database of 22 tertiary A general hospitals for all patients who used Shengmai injection and those who did not use Shengmai injection. The propensity scoring method was used to evaluate the possible existence of the research data. The confounding factors are controlled. Through the general Logistic regression analysis method, the propensity score weighted Logistic regression analysis method and the propensity score weighted Logistic regression analysis method with covariates, the therapeutic effect of Shengmai injection on angina pectoris was explored. Results: Three kinds of logistic regression analysis showed that there were statistical differences in the treatment effect of Shengmai injection on angina pectoris in the group without Shengmai injection. Propensity score weighted logistic regression analysis with covariates balanced the effect of multiple confounding factors. Using real-world data to construct a retrospective cohort study confirmed the clinical effectiveness of Shengmai injection in the treatment of angina pectoris, and at the same time confirmed the wide application of Shengmai injection in angina pectoris complicated with multiple organ failure. Conclusion: Shengmai injection is effective in the treatment of angina pectoris. The weighted method of propensity score removes confounding factors, which improves the reliability of real-world research results.

Shengmai injectionAngina pectorisPropensity scoreReal world

Zong-Liang Yu、Chun-Quan Sun、Fu-Mei Liu、Long-Tao Liu、Yan-Ming Xie、Shu Chen

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Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China

Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China

School of Statistics,Renmin University of China,Beijing 100872,China

国家重点研发计划

2018YFC1707400

2022

海南医科大学学报(英文版)

海南医科大学学报(英文版)

ISSN：
年,卷(期)：2022.28(12)
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