首页|Study on the mechanism of Shengjiang Xiexin Decoction in the treatment of chemotherapy-induced diarrhea based on network pharmacology and molecular docking

Study on the mechanism of Shengjiang Xiexin Decoction in the treatment of chemotherapy-induced diarrhea based on network pharmacology and molecular docking

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  • NETL
  • NSTL
  • 万方数据
  • 维普
Objective: To explore the key targets and mechanism of Shengjiang Xiexin Decoction in the treatment of chemotherapy-induced diarrhea based on network pharmacological methods. Methods: The effective components and corresponding target proteins of Shengjiang Xiexin Decoction were screened by TCMSP, and the target of chemotherapy-induced diarrhea were screened by the GeneCards. R software was used to obtain the common targets of drugs and diseases, and the "component-target-disease" network diagram was constructed by Cytoscape3.8.0 software. The string datebase was used to draw the protein interaction (PPI) network, and the Bioconductor software was used to perform GO function and KEGG pathway enrichment analysis on effective targets. Result: The result showed that 216 components were screened and 276 effective targets were screened. There were 1764 chemotherapy-induced diarrhea targets. The 173 common targets were obtained through venn diagram. The GO function analysis found 2427 items of biological process, 168 items of molecular function and 79 items of cellular component. The KEGG pathway analysis found 169 items. Conclusion: The PPI network found that STAT3、AKT1、MAPK3、JUN、MAPK1、RELA、IL6、etc. may be the key targets for Shengjiang Xiexin Decoction in treatment of chemotherapy-induced diarrhea. GO biological processes include DNA-binding transcription factor activity, cytokine receptor binding, cytokine activity, response to lipopolysaccharide, cellular response to chemical stress and so on. The KEGG pathways involved mainly include Toll-like receptor signaling pathway, TNF signaling pathway, inlfuenza A signaling pathway、hepatitise B signaling pathway and other pathways, that Play the role of anti-inflammatory and repair barrier.

Shengjiang Xiexin decoctionChemotherapy-induced diarrheaNetwork pharmacologyMechanism of actionMolecular docking

Yu Gao、Jian-Rong Sun、Chao Deng、Li-Qun Jia

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Beijing University of Chinese Medicine,Beijing 100029,China

China-Japan Friendship Hospital,Beijing 100029,China

国家自然科学基金Special Fund for Capital Health DevelopmentNational Administration of Traditional Chinese Medicine of ChinaHospital Project of China-Japan Friendship Hospital

819040012018-1-40612019-ZX-0052019-1-QN-56

2022

海南医科大学学报(英文版)

海南医科大学学报(英文版)

ISSN：
年,卷(期)：2022.28(13)
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