首页|Clinical efficacy of Chinese herbal compound in the treatment of infertility with kidney deficiency: A meta-analysis
Clinical efficacy of Chinese herbal compound in the treatment of infertility with kidney deficiency: A meta-analysis
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Objective: Based on the current evidence system to evaluate the effect of traditional Chinese medicine compound on the clinical efficacy of infertility patients with kidney deficiency. Methods: Search the China Knowledge Resources Database (CNKI), Chinese Science and Technology Journal Database (VIP), China Academic Journal Database (Wanfang), PubMed, EMBASE, Ovid. The included studies are randomized controlled trials. The experimental group is Chinese medicine compound or Chinese medicine compound combined with western medicine, and the control group is western medicine. Two reviewers independently extracted and evaluated the literature data according to the Cochrane manual standards, and used Rev Man5.3 software for data synthesis and Meta-analysis. Results: 32 studies were selected, a total of 2715 cases of infertility patients. The clinical pregnancy rate of the experimental group and the control group[n=29, OR(95％CI)=2.47(2.07, 2.96), P<0.00001], the clinical total effective rate [n=20, OR(95％CI)=3.77(2.83, 5.03), P<0.00001], TCM syndrome score [n=14, MD (95％CI)=4.34 (3.08,5.61), P<0.00001], ovulation rate[n=20, OR(95％CI)=2.21(1.85,2.63), P<0.00001], the occurrence rate of two-way BBT [n=11, OR (95％CI)=2.65 (2.02, 3.48), P<0.00001]. The GRADE scoring results show that the level of evidence is low and very low. Conclusion: Traditional Chinese medicine compound can increase the clinical pregnancy rate and clinical total effective rate of infertility with kidney deficiency syndrome, improve the scores of Chinese medical syndromes, increase its ovulation rate and the occurrence rate of BBT bidirectional type, and confirm the clinical efficacy of Chinese medicine compound from the perspective of evidence-based medicine.
Chinese herbal compound prescriptionKidney deficiency syndromeInfertilityClinical curative effectMeta-analysis
Lei Zhang、Zhi-Juan Wu、Jian-Wei Zhang
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The First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Jinan 250014,China
Reproductive and Genetic Center of Integrated Traditional Chinese and Western Medicine,the Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011,China
山东省自然科学基金Traditional Chinese Medicine Science and Technology Development Program of Shandong Province
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