首页|Meta analysis of the effect of aerobic exercise on inflammatory factors and glucose and lipid metabolism in patients with type 2 diabetes mellitus
Meta analysis of the effect of aerobic exercise on inflammatory factors and glucose and lipid metabolism in patients with type 2 diabetes mellitus
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Objective: To explore the effects of aerobic exercise on the levels of inflammatory factors in patients with type 2 diabetes. Methods: Randomized controlled studies (RCTs) on the effects of aerobic exercise on inflammatory factors in patients with type 2 diabetes were searched from electronic databases. Two researchers independently screened the literatures for data extraction and quality assessment. Meta-analysis was performed using RevMan 5.4 software. Results: A total of 17 literatures were included, including 1186 patients. The results of Meta-analysis showed that aerobic exercise significantly reduced the plasma levels of CRP, TNF-α, IL-6, and leptin in T2DM patients, but did not significantly reduce the plasma concentration of adiponectin. However, the left and right asymmetry of the "inverted funnel" plot indicated that there was a certain publication bias in the included studies. Conclusion: Existing evidence shows that aerobic exercise has a good effect on the improvement of chronic inflammatory state in patients with type 2 diabetes mellitus, suggesting that lifestyle changes can play a good role in adjunctive therapy.