首页|Meta analysis of the effect of aerobic exercise on inflammatory factors and glucose and lipid metabolism in patients with type 2 diabetes mellitus

Meta analysis of the effect of aerobic exercise on inflammatory factors and glucose and lipid metabolism in patients with type 2 diabetes mellitus

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Objective: To explore the effects of aerobic exercise on the levels of inflammatory factors in patients with type 2 diabetes. Methods: Randomized controlled studies (RCTs) on the effects of aerobic exercise on inflammatory factors in patients with type 2 diabetes were searched from electronic databases. Two researchers independently screened the literatures for data extraction and quality assessment. Meta-analysis was performed using RevMan 5.4 software. Results: A total of 17 literatures were included, including 1186 patients. The results of Meta-analysis showed that aerobic exercise significantly reduced the plasma levels of CRP, TNF-α, IL-6, and leptin in T2DM patients, but did not significantly reduce the plasma concentration of adiponectin. However, the left and right asymmetry of the "inverted funnel" plot indicated that there was a certain publication bias in the included studies. Conclusion: Existing evidence shows that aerobic exercise has a good effect on the improvement of chronic inflammatory state in patients with type 2 diabetes mellitus, suggesting that lifestyle changes can play a good role in adjunctive therapy.

Aerobic exerciseType 2 diabetesRandomized controlled trialsMeta-analysis

Rui-Ying Guo、Ya-Lin Yu、Xue-Yan Zhang、Hui-Xin Li、Yu-Dong Su、Ding-Yang Tian、Min Dong、Bo Dong

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Shandong University of Traditional Chinese Medicine,Jinan 250014,China

Department of Cardiology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China

国家自然科学基金Taishan Scholars Foundation

81570729ts20190979

2022

海南医科大学学报(英文版)

海南医科大学学报(英文版)

ISSN:
年,卷(期):2022.28(15)
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