首页|Research progress of autophagy in acute lung injury induced by multiple factors

Research progress of autophagy in acute lung injury induced by multiple factors

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Autophagy is a highly conserved catabolic process, involving the degradation of cellular components, including damaged organelles, denatured proteins and various pathogens. It is a defense and stress mechanism for maintaining cell and tissue homeostasis. More and more evidences show that autophagy is closely related to many diseases. Acute lung injury is caused by intrapulmonary or extrapulmonary factors, with hypoxia and low lung compliance as the main manifestations. At present, its pathogenesis is not clear. It is known that the imbalance of inflammatory response and oxidative stress mechanism are the important mechanisms of its occurrence. The inflammatory response caused by acute lung injury has been reported to involve a series of changes in autophagy expression. Autophagy may be protective or harmful in acute lung injury. This article will summarize the respective roles of autophagy in acute lung injury caused by infectious factors (such as pathogen infection, lipopolysaccharide, sepsis) and non-infectious factors (acute pancreatitis, chlorine poisoning), so as to provide new ideas and strategies for better prevention of acute lung injury.

AutophagyAcute lung injuryInfectious factorsNon-infectious factors

Qiu-Cheng Li、Qi Li、Pan-Hong Jia、Shao-Ning Li、Xiao-Man Xiong、Xiang-Dong Zhou

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Department of Respiratory Medicine,the First Affiliated Hospital of Hainan Medical College,Haikou 570102,China

Key Laboratory of Hainan Trauma and Disaster Rescue,Haikou 571199,China

Research Unit of Island Emergency Medicine,Chinese Academy of Medical Sciences 2019RU013,Hainan Medical University,Haikou 571199,China

Hainan Natural Science Foundation for Innovation Research TeamHainan Key Research and Development International Science and Technology Cooperation ProjectScientific and Technology Cooperation of Key Research and Development in Hainan ProvinceMajor Science and Technology Special Projects in Hainan Province国家自然科学基金国家自然科学基金国家自然科学基金Hainan Provincial Clinical Medical Center

820CXTD448GHYF2022011ZDYF2020223ZDKJ2021036818600018201153004982160012

2022

海南医科大学学报(英文版)

海南医科大学学报(英文版)

ISSN：
年,卷(期)：2022.28(15)
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