首页|Analysis of laboratory and imaging examination results of patients with COVID-192 years after discharge in Chengdu

Analysis of laboratory and imaging examination results of patients with COVID-192 years after discharge in Chengdu

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Objective: To summarize the follow‑up results of laboratory examination, echocardiographic and chest CT of patients with COVID‑19 at the time of 2 years after discharge in Chengdu. Methods: A total of 29 COVID‑19 survivors who have participated in the 1‑year follow‑up and 2‑year follow‑up at Public Health Clinical Center of Chengdu were included in our study. Their blood laboratory tests, echocardiography and chest CT results were analyzed in order to evaluate the long‑term recovery of COVID‑19 survivors. Results: The most common abnormal laboratory test results at the 2‑year follow‑up were increased serum fibronectin (21 cases, 72.4％) and decreased NK cell counts (19 cases, 65.5％). Compared with laboratory test results at the 1‑year follow‑up, platelet count, hydroxybutyrate dehydrogenase and creatine kinase isoenzyme were decreased (all P<0.05), while serum fibrinogen, triglyceride, insulin and non‑specific immunoglobulin A were increased (all P<0.05). Serum specific total SARS‑CoV‑2 antibody amount in COVID‑19 survivors at half a year after COVID‑19 vaccine was significantly higher than that before vaccination. More than half of patients (55.2％) had normal echocardiography results at the 2‑year follow‑up, the main abnormal results of them were valve regurgitation (7 cases, 24.1％) and reduced left ventricular diastolic function (9 cases, 31.0％). Compared with 1‑year follow‑up, 7 patients had fewer abnormal cardiac ultrasound results. 28 cases underwent chest CT at the 2‑year follow‑up, the mainly abnormal results were ground glass shadow (17.9％), pulmonary nodules (diameter<6mm) (32.1％) and scattered cable shadow (39.3％). 71.4％ (20/28) of them had no significant change between the two chest CT results. Conclusion: The mainly abnormal blood laboratory indicators in COVID‑19 survivors at 2‑year follow‑up after discharge were increased serum fibronectin and decreased NK cell counts. Although echocardiography and chest CT results were no significant change between 1‑year follow‑up and 2‑year follow‑up among COVID‑19 survivors, there were still some patients whose abnormal results were decreasing. Serum specific total SARS‑CoV‑2 antibody amount in COVID‑19 survivors at half a year after COVID‑19 vaccine was still significantly higher than that before vaccination, but the amount of specific antibody had a downward trend with time.

COVID‑19SARS‑CoV‑2Follow‑upLaboratory testVaccination

Zhao Ben-Nan、Du Qing、Kang Jun、Liu Da-feng、Zhang Ling、Lan Li-juan、Yuan Yuan

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Department of Comprehensive Internal Medicine,Public Health Clinical Center of Chengdu,Chengdu 610061,China

Department of Infectious Diseases,the First Affiliated Hospital of Chengdu Medical College,Chengdu 610513,China

Chengdu Municipal High level Clinical Key Specialty Construction Project Infectious Diseases Special ProjectChengdu Municipal Health Commission ProjectChengdu Municipal Science and Technology Bureau Project

20212502021?YF05?00536?SN

2022

海南医科大学学报(英文版)

海南医科大学学报(英文版)

ISSN：
年,卷(期)：2022.28(17)
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