Exploration of the effective components and mechanism of Alpinia oxyphylla-Saposhnikovia Radix in the treatment of diabetic kidney disease based on network pharmacology

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外文摘要：Objective: Network pharmacology was used to predict the main targets and related mechanism pathways of the key compounds and active ingredients of the Alpinia oxyphylla-Saposhnikovia Radix based on the therapeutic strategy of tonifying kidney and dispelling pathogenic wind for the treatment of diabetic kidney disease(DKD). Methods: The effective components of Alpinia oxyphylla-Saposhnikovia Radix were screened through the data platform of Traditional Chinese Medicine(TCM). After screening effective targets, the disease target gene database was used to obtain targets for DKD, and then gene enrichment analysis to predict relevant signalling pathways after obtaining the key target genes through Venn analysis. Results: There were 324 active components of Alpinia oxyphylla-Saposhnikovia Radix through the data platform of TCM. In addition, Venn analysis showed that there were 48 key target genes for the treatment of DKD. The biological pathways for the action of Alpinia oxyphylla-Saposhnikovia Radix in DKD were closely related to many signaling pathways including NF-kappaB, classical MAP kinase, JNK and P38 MAP kinase, and ERK5. Conclusions: Treatment of DKD with Alpinia oxyphylla-Saposhnikovia Radix based on the therapeutic strategy of tonifying kidney and dispelling pathogenic wind has the characteristics of multi-components, multi-targets and multi-pathways, which could provide new ideas and methods for further researches on the treatment of DKD with Alpinia oxyphylla-Saposhnikovia Radix.

外文关键词：

Diabetic kidney diseaseTonifying kidney and dispelling pathogenic windAlpinia OxyphyllaSaposhnikovia RadixNetwork pharmacology

作者：

Rui Kai、Wang Xian、Zhao Jing-Yu、Ma Tian-Peng、Jiang Huan、Yang Xu、Xie Yi-Qiang、Li Kai

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作者单位：

Hainan Medical University,Haikou 571199,China

基金：

国家自然科学基金海南省自然科学基金Scientific Research Cultivation Fund of Hainan Medical UniversityScientific Research Cultivation Fund of Hainan Medical University

项目编号：

82160897820RC635HYPY201924HYPY2020037

出版年：

2022

海南医科大学学报(英文版)

ISSN：

年,卷(期)：2022.28(17)

参考文献量19