首页|Effect of Shengsui Jiangu Capsule on bone conversion in rats with alcoholic osteoporosis
Effect of Shengsui Jiangu Capsule on bone conversion in rats with alcoholic osteoporosis
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NETL
NSTL
万方数据
维普
Objective: To study the mechanism of Shengsui Jiangu Capsule promoting vitamin D3 regulating bone turnover in rats with alcoholic osteoporosis. Methods: 120 SD rats were randomly divided into four groups: model group (alcoholic osteoporosis model group), blank control group, western medicine control group (calcium carbonate tablet and affa D3 control group), Chinese medicine experimental group (Shengsui Jiangu capsule experimental group), 30 rats in each group. After 8, 12 and 16 weeks, the serum levels of 25 hydroxyvitamin D3 (25(OH)D3),1,25dihydroxyvitamin D3 (1,25(OH)2D3), cross-linked carboxy-terminal peptide of type 1 collagen (β-CTX) and N-terminal propeptide of type 1 collagen (P1NP) in rats and the density of the femur of rats were detected and compared. The correlation between vitamin D3 markers (25(OH)D3 and 1,25(OH)2D3) and bone turnover indices (P1NP and β-CTX) and bone mineral density was analyzed. Results: In the experimental group, bone mineral density (BMD) was significantly increased (P<0.01), bone repair and mineral stability and balance were maintained during bone turnover, the level of bone formation marker P1NP was significantly increased (P<0.01), and the level of bone resorption marker β-CTX was significantly decreased (P<0.01). Serum levels of 25(OH)D3 and 1,25(OH)2D3 were increased (P<0.01), and significantly higher than those in western medicine control group (P<0.05). Conclusion: Shengsui Jiangu capsule can effectively improve bone density in alcoholic osteoporosis (AOP) rats, and its mechanism may be related to promoting bone calcium absorption and regulating bone conversion.
Shengsui Jiangu CapsuleAlcoholic osteoporosisVitamin D3Bone transformationMechanism of action
NETL
NSTL
万方数据
维普
