首页|Clinicopathological significance and prognostic value of claudin10 expression in primary malignant tumors of digestive system: A metaanalysis
Clinicopathological significance and prognostic value of claudin10 expression in primary malignant tumors of digestive system: A metaanalysis
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Objective: To investigate the correlation between claudin10 expression and clinicopathological characteristics and prognosis of primary malignant tumors of digestive system. Methods: We searched the PubMed, Web of Science, Ovid MEDLINE, CNKI, CQVIP, and WanFang Data databases. The data between claudin10 expression and clinical characteristics as well as survival outcome were extracted. RevMan 5.3 and Stata 15.1 software were employed for metaanalysis. Results: A total of 6 studies containing 512 patients with primary malignant tumors of digestive system were analyzed. The analysis showed that high expression of claudin10 was more common in cancer tissue than in normal tissue[OR=3.22, 95％CI(2.26, 4.60), P<0.01], and was associated with increasing tumor size [OR=6.21, 95％CI(2.44, 15.83), P<0.01], high differentiation [OR=0.56, 95％CI(0.32, 0.99), P=0.05], positive lymph node metastasis [OR=3.41, 95％CI(1.09, 10.65), P=0.03]. The expression of claudin10 was not associated with sex[OR=1.62, 95％CI(0.91, 2.90), P=0.10],age[OR=1.72, 95％CI(0.97, 3.07), P=0.06], distant metastasis[OR=4.51, 95％CI(0.55, 36.70), P=0.16], or prognosis[HR=1.99, 95％CI(0.93, 4.23), P=0.08]. Conclusion: The expression of claudin10 is correlated with the clinicopathological features of primary malignant tumors of digestive system and is a potential tumor marker.
Claudin-10Primary malignant tumor of digestive systemMeta-analysisClinicopathological characteristicsPrognosis
ZHOU Wen、WANG Qing-song
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Department of Histology and Embryology,Hainan Medical University,Haikou 571199,China
Department of Biochemistry and Molecular Biology,Hainan Medical University,Haikou 571199,China
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