首页|Clinical evaluation of Fufangkushen combined with oxaliplatin in the treatment of advanced colorectal cancer

Clinical evaluation of Fufangkushen combined with oxaliplatin in the treatment of advanced colorectal cancer

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Objective: To systematically evaluate the efficacy and safety of compound Kushen injection combined with oxaliplatin chemotherapy in the treatment of advanced colorectal cancer. Methods: We searched PubMed, EMbase, the Cochrane Library, CNKI, VIP and Wan Fang database, SinoMed to collect compound Kushen injection combined with chemotherapy oxaliplatin into treatment of advanced colorectal cancer in randomised controlled trials; the databases weresearched from inception to December 2020. Meta‑analysis of the included studies was performed using RevMan 5.4. Results: A total of 34 randomized controlled trials involving 2664 patients with colorectal cancer were included. Results of Meta‑analysis showed that compound Kushen injection combined with oxaliplatin chemotherapy regimen improved the objective response rate of tumor [RR=1.40, 95％CI(1.29,1.51), P<0.00001] and disease control rate [RR=1.12, 95％CI(1.08,1,16), P 0.00001] improved the quality of life [RR=1.24, 95％CI(1.14,1.36), P<0.00001], and significantly reduced the incidence of leukopenia [RR=0.35,95％CI(0.23,0.52), P<0.00001] and the incidence of diarrhea [RR=0.36, 95％CI(0.19,0.70), P=0.003], and improved the immune function of patients (CD3+, CD4+, CD4+/CD8+, NK cell levels). However, compared to the control group, the levels of CD8+ cells were decreased in the experimental group. Conclusion: Compound Kushen injection combined with oxaliplatin chemotherapy regimen can significantly improve the clinical efficacy of advanced colorectal cancer patients, improve the quality of life of patients, reduce the occurrence of adverse reactions, and has good efficacy and safety comparison with oxaliplatin chemotherapy regimen alone.

FufangkushenChemotherapyAdvanced colorectal cancerCurative effectSecurityMeta analysis

ZHOU Tong、WANG Shuo、HU Shuai-hang、LI Zheng、FAN Bing-jie、LI Jing-lei、HOU Wei

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Guang'anmen Hospital Affiliated to China Academy of Chinese Medical Sciences,Beijing 100053,China

China Academy of Chinese Medical Sciences,Beijing 100700,China

国家自然科学基金National Clinical Base of Traditional Chinese Medicine Business Construction Research ProjectEvidence based Medicine Program of China Academy of Chinese Medical Sciences

82071421252015ZSB01K?858

2022

海南医科大学学报(英文版)

海南医科大学学报(英文版)

ISSN：
年,卷(期)：2022.28(20)
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