首页|In vitro study on the antiviral activity of 9 extracts of traditional Chinese herbal medicine against the human respiratory syncytial virus

In vitro study on the antiviral activity of 9 extracts of traditional Chinese herbal medicine against the human respiratory syncytial virus

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Objective: To study the in vitro virucidal activity of 9 extracts of traditional Chinese herbal medicine (the water extracts of Evodia lepta, Clausena lansium, Clerodendrum cyrtophyllum, Callicarpa nudiflora, Nauclea officinalis and Elaeagnus gonyanthes, the alcohol extracts of Nauclea officinalis, Elaeagnus gonyanthes and Zanthoxylumarmatum)on human respiratory syncytial virus (HRSV). Methods: The cytotoxic effect of the extracts on cells was evaluated by a cell viability assay using the CCK-8 method, a concentration of the extracts with cell viability greater than 50％ was selected for the follow-up anti-HRSV effect assay, the 50％ effective concentration (EC50) was assessed by an in vitro cell infection model. Results: The EC50s of the water extract from Clerodendrum cyrtophyllum, Callicarpa nudiflora and Elaeagnus gonyanthes were 0.05 mg/mL, 0.03 mg/mL and 0.05 mg/mL, and the therapeutic index (TI) of them were 18.60, 21.67 and 56.80 respectively. Conclusion: The water extracts of Clerodendrum cyrtophyllum, Callicarpa nudiflora and Elaeagnus gonyanthes possess the activity of anti-HRSV virus.

Traditional Chinese herbal medicineHuman respiratory syncytial virusCytotoxicityAntiviral effectTherapeutic index

HU Xiao-yuan、YIN Fei-fei、ZHANG Jun-qing、LI Yong-hu、ZHANG Xu-guang

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Key Laboratory of Tropical Translational Medicine of Ministry of Education,Hainan Medical University,Haikou 571199,China

Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases,Hainan Medical University,Haikou 571199,China

Hainan Provincial Key Laboratory of R&D on Tropic Plants,Hainan Medical University,Haikou 571199,China

Haikou Key Laboratory of Li Nationality Medicine,Hainan Medical University,Haikou 571199,China

School of Pharmacy,Hainan Medical University,Haikou 571199,China

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Key Science and Technology Project of Hainan Province海南省自然科学基金海南省自然科学基金海南省自然科学基金

ZDKJ202003821QN2622019RC207820RC628

2022

海南医科大学学报(英文版)

海南医科大学学报(英文版)

ISSN：
年,卷(期)：2022.28(21)
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