首页|Systematic review and meta-analysis on efficacy of traditional Chinese medicine in treatment of inflammatory factors in patients with post-stroke depression
Systematic review and meta-analysis on efficacy of traditional Chinese medicine in treatment of inflammatory factors in patients with post-stroke depression
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NSTL
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维普
Objective: To systematically evaluate the effect of traditional Chinese medicine on inflammatory factors in patients with post-stroke depression (PSD) and the efficacy of traditional Chinese medicine on PSD. Methods: Chinese databases (Sinomed, CNKI, VIP, Wanfang), PubMed, Cochrane Library, and Web of Science were searched. Randomized controlled trials of patients with PSD treated with traditional Chinese medicine were included. Quality evaluation was performed and Meta-analysis was performed using RevMan 5.4 software. Results: The results show that TCM therapy is superior to western medicine in reducing the level of TNF-α [MD=-4.13,95％ CI(-4.75,-3.51), P<0.00001], IL-6 [MD=-3.39,95％ CI(-3.90,-2.88),P<0.00001] and IL-8 [MD=-2.12,95％ CI(-2.49,-1.75),P<0.00001] in venous blood of PSD patients, and is superior to western medicine in reducing the score of HAMD [MD=-4.22,95％ CI(-5.37,-3.07),P<0.00001] and NIHSS [MD=-2.33,95％ CI(-3.43,-1.23),P<0.0001]. The combination of Chinese medicine and western medicine is superior to western medicine in reducing the level of TNF-α [MD=-10.61,95％ CI(-15.30,-5.91),P<0.00001]、IL-1 [MD=-3.75,95％ CI(-4.51,-2.99),P<0.00001]、IL-6 [MD=-3.83,95％ CI(-4.49,-3.16),P<0.0001]、IL-8 [MD=-9.41,95％ CI(-14.89,-3.92),P<0.00001] and Hcy [MD=-3.81,95％ CI(-4.62,-2.99),P<0. 00001] in venous blood of patients with PSD, and is superior to western medicine in reducing the score of HAMD [MD=-3.06,95％ CI(-3.39,-2.73),P<0.00001]、NIHSS [MD=-4.47,95％ CI(-7.55,-1.39),P=0.004] and HAMA [MD=-2.83,95％ CI(-3.47,-2.19),P<0.00001] and improving BI index. Three studies do not mention adverse reactions, and 37 cases in the remaining three studies show rash, tremor, dizziness and other adverse reactions. The incidence of adverse reactions in the experimental group was lower than that in the control group, and there were no serious adverse reactions. Conclusion: The results suggest that traditional Chinese medicine can reduce the level of some inflammatory factors in patients with PSD to a certain extent, and its efficacy is better than that of western medicine alone. Nevertheless, this study has some limitations, and with the increase of related trials in the future, the conclusions of the study need to be further discussed by adding more high-quality RCT studies.
Chinese medicinePost-stroke depressionCytokineInflammationMeta-analysis
WANG Hui-ying、GOU Jin、YANG Li-xuan、GUO Rong-juan
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Beijing University of Chinese Medicine,Beijing 100029,China
Dongfang Hospital of Beijing University of Chinese Medicine,Second Department of Neurology,Beijing 100078,China
Key Research Project of the University国家自然科学基金北京市自然科学基金
NETL
NSTL
万方数据
维普
