首页|Clinical characteristics of 72 cases with neuromyelitis optical associated optic neuritis
Clinical characteristics of 72 cases with neuromyelitis optical associated optic neuritis
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NETL
NSTL
万方数据
维普
Objective: To analyze the clinical characteristics of neuromyelitis optical associated optic neuritis (NMO-ON) patients, and to provide reference and basis for the prevention and treatment accordingly. Methods: The medical records of 72 NMO patients with ON as the first clinical manifestation in China-Japan Friendship Hospital from January 2016 to December 2019 were retrospectively analyzed and summarized, including general information, morbidity characteristics, course of disease, comorbid diseases, immunological tests, treatment response and prognosis, etc. Results: Totally 72 NMO-ON patients had a median age of 33 years. The ratio of male to female is about 1:5.54; The median course was 67 months, mainly "relapse-remission". Totally 61.11％ patients were successively involved in both eyes, the median incidence of ON was 2 times, and the median time of the second onset of ON was 3 months. The 1-year and 3-year recurrence rates were 55.56％ and 73.61％, respectively. Around 91.67％ of the patients had the onset of ON alone, and 81.94％ of the patients had monocular involvement. About 19.44％ patients were associated with inducement, the most common was upper respiratory tract infection; 15.28％ patients were associated with systemic immune diseases, most commonly associated with Sjogren's syndrome and thyroid diseases and 75.64％ patients had first visual acuity less than 0.1, aquaporin-4 immunoglobulin G (AQP4-IgG) status (P=0.032, OR =2.55) and onset age (P=0.037, OR=3.93) were independent risk factors for first visual acuity. Up to the last follow-up time, the rate of unilateral blindness was about 48.61％, and the median of unilateral blindness ON was 2 times. Other nervous system involvement occurred in 73.61％ of patients, and spinal cord (61.11％) was the most common site of recurrence. Serum AQP4-IgG was positive in 80.00％ (48/60) of patients. A total of 18 cases (25.00％) were associated with other systemic immune antibodies, most commonly associated with ANA antibody positivity. Conclusions: The first onset of NMO-ON patients is mostly ON alone, with unilateral involvement and high incidence in young and middle-aged women. Bilateral optic nerve involvement and repeated recurrence are common in the long course of disease. AQP4-IgG status and onset age are independent risk factors affecting the visual function of NMO patients for the first onset, and most patients have positive AQP4-IgG serum. Some patients are associated with systemic immune diseases represented by Sjogren's syndrome and thyroid disease, which are at high clinical risk and require early diagnosis and treatment intervention.
Optic neuromyelitisOptic neuritisClinical features
HAN Meng-yu、QIN Ya-li、JIAO Yu-juan、JIAO Jin-song、MA Chuan-zheng、JIN Ming
NETL
NSTL
万方数据
维普
