首页|A nomogram model for predicting the prognosis of colorectal cancer patients based on preoperative Fbg, PAR and CA199

A nomogram model for predicting the prognosis of colorectal cancer patients based on preoperative Fbg, PAR and CA199

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Objective: To construct a nomogram model for predicting the prognosis of colorectal cancer patients based on preoperative fibrinogen (Fbg), platelet to albumin ratio (PAR) and carbohydrate antigen 199 (CA199). Methods: In this retrospective study, we included 323 patients who underwent colorectal cancer (CRC) surgery in our hospital. The preoperative test indexes and relevant clinicopathological data of the patients were collected. According to the cut-off value of Fbg and PAR calculated from the receiver operating characteristic (ROC) curve, they were divided into the high and low expression groups. Univariate and multivariate Cox proportional hazards models were used to screen independent prognostic factors which were used to construct a nomogram. Results: According to ROC curve, the cut-off values of Fbg and PAR were 2.80 and 6.05. Multivariate Cox regression analysis showed that Fbg, PAR, CA199, TNM stage and grade were independent risk factors affecting the prognosis of patients (P <0.05). Fbg, PAR, and CA199 jointly built the risk score that was included into the nomogram. The area under the curve (AUC) in the ROC of the training and verification set was greater than 0.6. The calibration curve and ideal curve fit well. Conclusion: The nomogram based on Fbg, PAR and CA199 has well accuracy and can provide individualized prediction for the overall survival of CRC patients.

Colorectal canceFibrinogenPlatelet to albumin ratioCarbohydrate antigen 19-9NomogramPrognosis

LIU Xiu-ling、YU Hua-yi、QI Guo-ping、LU Wen-bin、LIU Qian、YANG Yu-wei、DENG Jian-zhong

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Department of Oncology,Wujin Hospital Affiliated to Jiangsu University/Wujin Clinical College of Xuzhou Medical University/Changzhou Key Laboratory of Molecular Diagnostics and Precision Cancer Medicine,Changzhou 213017,China

国家自然科学基金High Level Health Talents of Jiangsu Provincial Health CommissionApplied Basic Research Project of Changzhou Science and Technology Bureau

81872275LGY2018017CJ20220006

2022

海南医科大学学报(英文版)

海南医科大学学报(英文版)

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年,卷(期)：2022.28(24)
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