The Predictive Value of Serum GFAP and MMP-9 Detection for Neurological Damage in Patients with Hypertensive Intracerebral Hemorrhage
[Objective]To explore the relationship between glial fibrillary acidic protein(GFAP),matrix metalloproteinase-9(MMP-9)and the degree of neurological damage in patients with hypertensive intracere-bral hemorrhage(HICH).[Methods]A total of 102 HICH patients and 85 hypertensive patients without cere-bral hemorrhage were recorded as HICH group and hypertensive group,respectively.Another 80 healthy indi-viduals who underwent physical examination were selected as the health group.Three groups of GFAP and MMP-9 levels were compared;The National Institutes of Health Stroke Scale(NIHSS)was used to evaluate the degree of neurological damage in HICH patients,and based on this,they were divided into mild,moder-ate,and severe groups.We compared the levels of GFAP and MMP-9 in HICH patients with different degrees of neurological deficits.Pearson correlation analysis was used to investigate the correlation between GFAP,MMP-9 levels and the degree of neurological damage in HICH patients.After a 6-month follow-up,the prog-nosis of HICH patients was evaluated based on the Glasgow Outcome Scale(GOS),and the levels of GFAP and MMP-9 were compared between the group with good prognosis and the group with poor prognosis.A re-ceiver operating characteristic curve(ROC)was created to analyze the predictive value of GFAP,MMP-9,and their combination on the prognosis of HICH patients using area under the curve(AUC).[Results]The levels of GFAP and MMP-9 in patients with hypertension and HICH were higher than those in the healthy group(P<0.05);The levels of GFAP and MMP-9 in the HICH group were higher than those in the hypertension group(P<0.05).The levels of GFAP and MMP-9 in patients in the moderate and severe groups were higher than those in the mild group(P<0.05);The levels of GFAP and MMP-9 in the severe group were higher than those in the moderate group(P<0.05).The levels of GFAP and MMP-9 in HICH patients are positively cor-related with the degree of neurological damage(P<0.05).The levels of GFAP and MMP-9 in the poor prog-nosis group were higher than those in the good prognosis group(P<0.05).The ROC results showed that the AUC of GFAP,MMP-9,and their combination for predicting the prognosis of HICH patients were 0.978,0.884,and 0.925,respectively.GFAP had the highest predictive value for the prognosis of HICH patients.[Conclusion]Serum levels of GFAP and MMP-9 are related to the degree of neurological damage and prognosis in HICH patients,and have a high predictive power for patient prognosis.
万方数据
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