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急性心肌梗死冠状动脉微循环阻力指数的影响因素分析

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[目的]探讨急性心肌梗死(AMI)冠脉微循环阻力指数(IMR)的影响因素.[方法]选择 2019 年 3 月至2021 年 6 月本院收治的 67 例 AMI患者,采用二分类法以 IMR正常值 25 为界值将患者分为正常 IMR 组(对照组,n =29,IMR≤25)和观察组(n =38,IMR>25).比较两组患者临床资料,采用 Pearson相关性分析 IMR 与各临床因素之间的关系,应用多因素 Logistic回归曲线分析各临床指标与高水平 IMR 的相关性.[结果]观察组患者年龄、低密度脂蛋白胆固醇(LDL-C)、心肌肌钙蛋白I(cTnI)及肌酸激酶同工酶(CK-MB)、病变血管长度高于对照组,术后TIMI血流分级、左室射血分数(LVEF)低于对照组,差异有统计学意义(P<0.05).Pearson相关性分析显示,IMR与 cTnI、年龄呈正相关(P<0.05),与术后 TIMI血流分级、LVEF呈负相关(P<0.05);IMR与病变血管长度、CK-MB无显著相关性(P>0.05).多因素 Logistic 回归分析结果显示,cTnI、术后 TIMI 血流分级、LVEF是 IMR的影响因素,其优势比(OR)(95%CI)分别为 2.01(1.02~3.88)、1.03(0.87~1.95)、0.36(0.07~0.93),差异均有统计学意义(P<0.05).[结论]cTnI、术后 TIMI 血流分级、LVEF 是 AMI 患者 IMR 的影响因素.
Analysis of Factors Influencing Coronary Microcirculatory Resistance Index in Acute Myocardial Infarction
[Objective]To explore the influencing factors of coronary microcirculation resistance index(IMR)in acute myocardial infarction(AMI).[Methods]A total of 67 AMI patients admitted to our hospital from March 2019 to June 2021 were selected in the study and they were divided into a normal IMR group(the control group,n =29,IMR≤25)and an observation group(n =38,IMR>25)using a binary classification method with a normal IMR value of 25 as the cutoff.Clinical data of the two groups of patients were compared,using Pearson correlation analysis to analyze the relationship between IMR and various clinical factors and multivariate logistic regression curve to analyze the correlation between various clinical indicators and high-level IMR.[Results]The results showed that the age,LDL-C(low-density lipoprotein cholesterol),cTnI(cardiac troponin I),CK-MB(creatine kinase isoenzyme),and lesion vessel length of the observation group were higher than those of the control group,while the postoperative TIMI blood flow grade and LVEF(left ventricular ejection fraction)were lower than those of the control group,with statistically significant differences(P<0.05).Pearson correlation analysis showed that IMR was positively correlated with cTnI and age(P<0.05),but negatively correlated with postoperative TIMI blood flow grading and LVEF(P<0.05).There was no significant correlation between IMR and lesion vessel length,and no correlation was seen between IMR and CK-MB(P>0.05).Multivariate logistic regression analy-sis showed that cTnI,postoperative TIMI blood flow grade,and LVEF were the influencing factors of IMR,with odds ratios(OR)(95%CI)of 2.01(1.02-3.88),1.03(0.87-1.95),and 0.36(0.07-0.93),respectively,with statistical significance(P<0.05).[Conclusion]The cTnI postoperative TIMI blood flow grading and LVEF are the influencing factor.

Myocardial InfarctionAcute DiseaseCoronary CirculationRoot Cause Analysis

肖红芳、姜艳艳

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北京中医药大学孙思邈医院,陕西 铜川 727000

心肌梗死 急性病 冠状动脉循环 影响因素分析

2024

医学临床研究
湖南省医学会

医学临床研究

影响因子:0.595
ISSN:1671-7171
年,卷(期):2024.41(2)
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