The Relationship between Platelet Parameters,Platelet Reactive Protein 1 Levels,and Disease Ac-tivity in Patients with Systemic Lupus Erythematosus
[Objective]To explore the relationship between platelet(PLT)related parameters,PLT reactive protein 1(TSP-1)levels,and disease activity in patients with systemic lupus erythematosus(SLE).[Methods]A total of 83 SLE patients admitted to our hospital were selected as the observation group,and 62 healthy individuals who underwent physi-cal examinations during the same period were selected as the control group.Two groups of general information,biochemi-cal indicators,PLT related parameters,and TSP-1 levels were compared;Logistic multiple regression analysis was used to identify the factors influencing disease activity in SLE patients,and receiver operating characteristic(ROC)curve anal-ysis was used to evaluate the value of PLT parameters and TSP-1 in evaluating disease activity in SLE patients.[Results]The PLT count,PLT volume,and percentage of large PLT in the observation group were all lower than those in the con-trol group(P<0.05).The average PLT volume(MPV),PLT volume distribution width(PDW),and TSP-1 level in the observation group were higher than those in the control group(P<0.05).Logistic multiple regression analysis showed that IgG,MPV,C3,C4,PLT,and TSP-1 levels were related factors affecting disease activity in SLE patients(P<0.05).ROC curve analysis showed that the sensitivity of MPV,PLT,TSP-1,and their combined evaluation for disease activity in SLE patients were 72.41%,75.86%,68.97%,and 79.31%,respectively.The specificity was 70.37%,79.63%,77.78%,and 83.33%,respectively.The area under the curve(AUC)was 0.723,0.751,0.739,and 0.892,respectively.[Conclusion]MPV,PLT,and TSP-1 in PLT parameters are related to disease activity in SLE pa-tients,and their combined evaluation of disease activity in SLE patients has good efficacy as evaluation indicators.
万方数据
维普
