The Clinical Efficacy of the Combination of Butylphthalide and Gangliosides in the Treatment of A-cute Cerebral Infarction and its Impact on the Neurological Function of Patients
[Objective]To explore the clinical efficacy of the combination of butylphthalide and gangliosides in the treatment of acute cerebral infarction(ACI)and its impact on the neurological function of patients.[Methods]A total of 98 ACI patients admitted to our hospital from March 2021 to December 2022 were selected and randomly divided into a control group and an observation group using a random number table method,with 49 cases in each group.The control group re-ceived treatment with gangliosides,while the observation group received treatment with a combination of butylphthalide and gangliosides.We compared two groups of clinical total effective rates,related scores[Barthel Index Rating Scale(BI),Stroke Specific Quality of Life Scale(SS-QOL),National Institutes of Health Stroke Scale(NIHSS)],neurological func-tion indicators[Neuron Specific Enolase(NSE),Central Nervous System Specific Protein(S100β),Myelin Basic Protein(MBP)]levels,hemodynamic indicators(WBV,FIB)Blood cell hematocrit(HCT),coagulation factor(PV),and serum levels of vascular endothelial growth factor(VEGF),trimethylamine oxide(TMAO),thromboxane A2(TXA2),and en-dothelin 1(ET-1).[Results]The total clinical effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the NIHSS score of the two groups of patients was lower than before treatment,while the BI score and SS-QOL score were higher than before treatment.The difference between the observation group and the control group was statistically significant(P<0.05);The levels of NSE,S100β,and MBP in both groups were lower than before treatment,while the observation group was lower than the control group,and the difference was statistically significant(P<0.05);The levels of HCT,WBV,FIB,and PV in the two groups of patients were lower than before treatment,and the observation group was lower than the control group,with sta-tistical significance(P<0.05);The serum VEGF levels of the two groups were higher than before treatment,while the levels of ET-1,TMAO,and TXA2 were lower than before treatment.The difference between the observation group and the control group was statistically significant(P<0.05).[Conclusion]The combination of butylphthalide and gangliosides has a good therapeutic effect on ACI,and improve the quality of life of patients.
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