The Correlation between Serum Myocardial Injury Markers and Inflammatory Factors with the Se-verity of Neonatal Asphyxia
[Objective]To explore the correlation between serum myocardial injury markers and inflammatory factors with the severity of neonatal asphyxia.[Methods]A total of 120 newborns with asphyxia born in our hospital from Sep-tember 2019 to September 2022(observation group)and 50 healthy newborns(control group)were selected.Two groups of study subjects were compared in terms of serum myocardial injury biomarkers[calcin I(cTnI),creatine kinase(CK),and creatine kinase isoenzyme(CK-MB)]and inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)],and the relationship between serum cTnI,CK,CK-MB,CRP,IL-6,TNF-αlevels and the severity of neonatal asphyxia was analyzed.[Results]The serum levels of cTnI,CK,CK-MB,CRP,IL-6,and TNF-αin the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The serum levels of cTnI,CK,and CK-MB in the severe asphyxia group were higher than those in the mild as-phyxia group on the 1st and 7th day of birth(P<0.05),and the serum levels of cTnI,CK,and CK-MB on the 7th day of birth were lower than those on the 1st day of birth in the two groups,with statistical significance(P<0.05).The se-rum levels of CRP,IL-6,and TNF-αin the severe asphyxia group were significantly higher than those in the mild as-phyxia group on the 1st and 7th day of birth(P<0.05).The serum levels of CRP,IL-6,and TNF-αin the two groups were lower on the 7th day of birth than on the 1st day of birth,and the difference was statistically significant(P<0.05).Spearman correlation analysis showed that serum levels of cTnI,CK,CK-MB,CRP,IL-6,TNF-αwere positively corre-lated with the severity of neonatal asphyxia(all P<0.05).[Conclusion]The levels of myocardial injury markers and in-flammatory factors in newborns with asphyxia are abnormally elevated,and the levels of myocardial injury markers and inflammatory factors are positively correlated with the severity of neonatal asphyxia.
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