[Objective]To investigate the efficacy of different doses of olanzapine in treating elderly depres-sion patients with comorbid anxiety and pain,as well as its effects on somatic symptoms and sleep quality.[Methods]A total of 120 elderly patients with depression plus comorbid anxiety and pain from our hospital were randomly divided into a low-dose group and a high-dose group,with 60 patients in each group.Both groups were treated with paroxetine,while patients in the control group received a high dose of olanzapine(10 mg/dose)and in the observation group received a low dose of olanzapine(2.5 mg/dose),both for three months.The effectiveness and adverse reactions of the two groups were compared.The scores on the Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA),Patient Health Questionnaire-15(PHQ-15)for the severity of somatic symptoms,Pittsburgh Sleep Quality Index(PSQI),and levels of fasting blood glucose(FBG),total cholesterol(TC)and triglycerides(TG)were compared before and after treatment in both groups.[Results]There was no significant statistical difference in the overall effectiveness rate between the two groups(P＞0.05).There were no significant statistical differences in the HAMD,HAMA,and PHQ-15 scores between the two groups either before or after treatment(P＞0.05),while there was a significant re-duction in the scores after treatment if compared to before treatment in each group(P＜0.05).There were no significant statistical differences in the individual and total PSQI scores between the two groups before and af-ter treatment(P＞0.05),however,the scores of both groups after treatment were significantly lower than those before treatment(P＜0.05).There were no significant statistical differences in levels of FBG,TC and TG between the two groups before treatment(P＞0.05).After treatment,the FBG,TC,and TG levels in the high-dose group were significantly higher than those before treatment,while the FBG,TC and TG levels of the high-dose group were significantly higher than those of the low-dose group(P＜0.05).The total incidence of adverse reactions in the low-dose group was significantly lower than that in the high-dose group(P＜0.05).[Conclusion]Olanzapine can improve depression,anxiety,somatic symptoms,and sleep quality in elderly pa-tients with depressive disorder plus comorbid anxiety and pain.Using a low dose of olanzapine can reduce the risk of hyperglycemia and hyperlipidemia,and it has fewer adverse reactions.
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