The Value of Echocardiographic Parameters,Peripheral Blood T Lymphocyte Subsets,NF-κB,and CD64 Levels in Predicting the Prognosis of Neonatal Sepsis
[Objective]To explore the value of echocardiographic parameters,peripheral blood T lympho-cyte subsets,nuclear factor-κB(NF-κB),and cluster differentiation antigen 64(CD64)levels in predicting the prognosis of neonatal sepsis.[Methods]A total of 95 neonatal sepsis patients admitted to our hospital from January 2020 to February 2023 were selected and divided into a survival group(n =80)and a death group(n =15)according to their prognosis.The echocardiographic parameters[left ventricular short axis shortening fraction(FS),ascending aorta diameter(AAO),left ventricular ejection fraction(LVEF)],myocardial injury markers[creatine kinase(CK),creatine kinase isoenzyme(CK-MB)],T lymphocyte subsets(CD3+,CD4+,CD8+),NF-κB,and CD64 levels were compared between the two groups.Logistic multivariable regression a-nalysis was used to analyze the relevant factors affecting the poor prognosis of neonatal sepsis.The receiver op-erating characteristic(ROC)curve was used to analyze the clinical value of electrocardiogram and laboratory in-dicators in predicting the prognosis of neonatal sepsis.[Results]There was no significant difference in the lev-els of creatine kinase CK and CK-MB between the two groups(P＞0.05).The FS,AAO,and LVEF in the survival group were higher than those in the death group,and the difference was statistically significant(P＜0.05).There was no significant difference in the CD8+ level between the two groups(P＞0.05).The CD3+ and CD4+ levels in the survival group were higher than those in the death group,while the NF-κB and CD64 levels were lower,and the difference was statistically significant(P＜0.05).There was no significant differ-ence in the NLR and CRP levels between the two groups(P＞0.05).The WBC level in the survival group was lower than that in the death group,and the difference was statistically significant(P＜0.05).Logistic multi-variable regression analysis showed that FS,LVEF,and CD64 were related factors affecting the prognosis of neonatal sepsis(P＜0.05).The area under the ROC curve for FS,LVEF,and CD64 combined to predict the prognosis of neonatal sepsis was 0.948,which was significantly higher than that of each individual indicator(0.827,0.895,and 0.877,respectively)(P＜0.05).[Conclusion]The combined detection of FS,LVEF,and CD64 has good predictive value for the prognosis of neonatal sepsis.Clinicians can closely monitor these indica-tors to timely judge the prognosis of neonatal sepsis and take relevant intervention measures.
万方数据
维普
