Relationship between Serum Inflammatory Factor Level and Cognitive Function in Patients with Ob-sessive-compulsive Disorder
[Objective]To explore the relationship between serum inflammatory factor levels and cognitive func-tion in patients with obsessive-compulsive disorder.[Methods]A total of 252 patients with obsessive-compulsive dis-order who were treated in our hospital were divided into the mild obsessive-compulsive disorder group(n =125)and the severe obsessive-compulsive disorder group(n =127)according to the Yale-Brown obsessive-compulsive scale(Y-BOCS).In the same period,100 healthy people who came to our hospital for physical examination were recruited to the control group.The changes of serum levels of interleukin-2(IL-2),levels of interleukin-6(IL-6),tumor nec-rosis factor-alpha(TNF-α)and serotonin 5-hydroxytryptamine(5-HT)levels were compared among different groups.The cognitive function of each group using the Neurocognitive Battery test(MCCB)was evaluated and com-pared as well.Spearman correlation test was used to analyzed the relationship of cognitive function score with serum levels of IL-2,IL-6,IL-8 and TNF-α.[Results]Information processing speed,visuospatial working memory,visual memory,reasoning and problem-solving scores,and 5-HT level in the obsessive-compulsive group were lower than those in the control group(P＜0.05).The serum levels of IL-2,IL-6,IL-8 and TNF-αin pre-treated obsessive-compulsive group were higher than those post-treated obsessive-compulsive group,which was greater than the con-trol group(P＜0.05).The information processing speed,visuospatial working memory,visual memory,reasoning and problem-solving scores,and 5-HT level before and after treatment in the severe obsessive-compulsive group were lower than those in the mild obsessive-compulsive group(P＜0.05),while the levels of IL-2,IL-6,IL-8 and TNF-αbefore and after treatment in the severe obsessive-compulsive group were significantly higher than those in the mild obsessive-compulsive group(P＜0.05).Spearman test showed that serum levels of IL-2,IL-6,IL-8 and TNF-αwere negatively correlated with information processing speed,visual spatial working memory,visual memo-ry,reasoning and problem-solving scores in patients with obsessive-compulsive disorder(P＜0.05).[Conclusion]Serum levels of IL-2,IL-6,IL-8 and TNF-αare important inflammatory indicators that reflect the cognitive function of patients with obsessive-compulsive disorder.IL-2,IL-6,IL-8 and TNF-αlevels are negative correlation with the cognitive function score of patients with obsessive-compulsive disorder.Thus they can be used as an auxiliary diag-nostic index to detect the cognitive impairment of patients with obsessive-compulsive disorder.
Obsessive-Compulsive DisorderChemokines/BLCognitionCorrelation of Data
万方数据
维普
