Effect of SEPT9 Gene Methylation Level in Cancer Tissue on postoperative Progression-free Sur-vival in Patients with Stage Ⅱ-Ⅲ Resectable Rectal Cancer
[Objective]To investigate the impact of SEPT9 gene methylation level in cancer tissues on pro-gression-free survival after surgery in patients with stage Ⅱ-Ⅲ resectable rectal cancer.[Methods]A total of 129 patients who underwent R0 total mesorectal excision for stage Ⅱ-Ⅲ resectable rectal cancer were fol-lowed up for 5 years postoperatively.The positive expression of SEPT9 gene methylation in cancer tissues and adjacent non-cancerous tissues was compared,and the relationship of SEPT9 gene methylation levels in cancer tissues with clinicopathological parameters was analyzed.Factors affecting postoperative recurrence or metasta-sis of rectal cancer were investigated,along with the relationship between positive expression of SEPT9 gene methylation in cancer tissues and progression-free survival after surgery.[Results]The positive expression rate of SEPT9 gene methylation in cancer tissues was higher than that in adjacent non-cancerous tissues(P＜0.05).Patients with poorly differentiated,N2 stage,stage Ⅲ,and tumor invasion into the vasculature had higher positive expression rates of SEPT9 gene methylation in cancer tissues than those with moderately to well-differentiated,N0-N1 stage,stage Ⅱ,and no tumor invasion into the vasculature(P＜0.05).Cox re-gression analysis showed that preoperative carcinoembryonic antigen levels,pathological staging,differentia-tion degree,and positive SEPT9 gene methylation were independent factors affecting postoperative recurrence or metastasis(P＜0.05).Patients with positive expression of SEPT9 gene methylation had lower progression-free survival rates than those with negative expression(P＜0.05).[Conclusion]The level of SEPT9 gene methylation in cancer tissues of patients with stage Ⅱ-Ⅲ resectable rectal cancer is related to clinicopatholog-ical parameters and prognosis.Patients with positive expression of SEPT9 gene methylation have a higher risk of postoperative recurrence and metastasis.
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