Diagnostic Value of HR-HPV DNA and LPT Detection in Patients with Cervical Squamous Cell Car-cinoma
[Objective]To investigate the diagnostic value of high-risk human papillomavirus(HR-HPV)de-oxyribonucleic acid(DNA)combined with liquid based thin-prep cytology(LPT)in cervical squamous cell carcino-ma.[Methods]A total of 84 patients with cervical squamous cell carcinoma(cervical squamous cell carcinoma group)and 60 patients with chronic cervicitis(chronic cervicitis group)who were diagnosed and treated in Xi'an High-tech Hospital from May 2019 to April 2021 were selected,and 50 healthy women who underwent physical examination in the Xi'an High-tech Hospital during the same period were selected as the control group.The posi-tive rates of HR-HPV DNA and LPT were compared among the three groups;The positive rates of HR-HPV DNA and LPT in patients with cervical squamous cell carcinoma at different stages and different degrees of differ-entiation were compared.Taking the pathological examination results as the gold standard,the diagnostic efficacy of HR-HPV DNA combined with LPT detection for cervical squamous cell carcinoma was analyzed.[Results]The positive rates of HR-HPV DNA and LPT in the cervical squamous cell carcinoma group and the chronic cervicitis group were higher than those in the control group(P＜0.05);The positive rates of HR-HPV DNA and LPT in cervical squamous cell carcinoma group were higher than those in the chronic cervicitis group.There was no signifi-cant difference in the positive rates of HR-HPV DNA and LPT in patients with cervical squamous cell carcinoma at different stages(P＞0.05);There was no significant difference in the positive rates of HR-HPV DNA and LPT in patients with cervical squamous cell carcinoma of different differentiation degrees(P＞0.05).Receiver operating characteristic(ROC)curve analysis showed that the sensitivity of HR-HPV DNA combined with LPT in the diag-nosis of cervical squamous cell carcinoma was significantly higher than that of HR-HPV DNA and LPT alone;The AUC of HR-HPV DNA combined with LPT in the diagnosis of cervical squamous cell carcinoma was higher than that of HR-HPV DNA and LPT alone(Z =3.940,P＜0.001;Z =3.968,P＜0.001).[Conclusion]HR-HPV DNA combined with LPT is highly effective in the diagnosis of cervical squamous cell carcinoma,and can be used as an important reference index for clinical diagnosis of cervical squamous cell carcinoma.
万方数据
维普
