Clinical Efficacy of Low Molecular Weight Heparin Combined with Alprostadil in the Treatment of Patients with Hyperlipidemic SAP
[Objective]To investigate the clinical efficacy of low molecular weight heparin combined with alprostadil in the treatment of patients with hyperlipidemic severe acute pancreatitis(SAP).[Methods]A total of 92 patients with hy-perlipidemic SAP admitted to our hospital from July 2020 to July 2022 were selected and randomly divided into an obser-vation group and a control group using a random number table method,with 46 cases in each group.The control group was treated with alprostadil on the basis of conventional treatment,while the observation group was treated with low mo-lecular weight heparin on the basis of the control group's treatment.The conditions of recovery,Ranson score,Sequential Organ Failure Assessment(SOFA)score,hemorheological indexes[D-dimer(D-D),plasma viscosity,fibrinogen(FIB),platelet aggregation rate],blood lipid levels[low density lipoprotein cholesterol(LDL-C),triglyceride(TG),high density lipoprotein cholesterol(HDL-C)],inflammatory factors[white blood cell count(WBC),tumor necrosis factor-α(TNF-α),procalcitonin(PCT)],and prognosis were compared between the two groups.[Results]After treatment,the mechani-cal ventilation time,abdominal pain subsidence time,ICU hospitalization time,and intestinal function recovery time in the observation group were shorter than those in the control group(P＜0.05);the Ranson score and SOFA score in both groups were lower than those before treatment,and the observation group was lower than the control group,with signifi-cant differences(P＜0.05);D-D,plasma viscosity,FIB,platelet aggregation rate in the observation group were lower than those before treatment,and those in the observation group were lower than those in the control group,with signifi-cant differences(P＜0.05);LDL-C,TG in both groups were lower than those before treatment,HDL-C was higher than those before treatment,LDL-C,TG in the observation group were lower than those in the control group,HDL-C was higher than those in the control group,with significant differences(P＜0.05);PCT,TNF-α,WBC in both groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P＜0.05).The total incidence of complications and recurrence rate in the observation group were lower than those in the control group,with significant differences(P＜0.05).[Conclusion]Low molecular weight heparin combined with alpros-tadil has better clinical efficacy in the treatment of hyperlipidemic SAP,which can promote patient recovery,improve mi-crocirculation,reduce lipids and inflammation,and help improve patient prognosis.
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