Effect of Initiation Timing of Continuous Renal Replacement Therapy on 28-Day Cumulative Survival Rate of Patients with Sepsis-induced Acute Kidney Injury
[Objective]To explore the impact of the initiation timing of Continuous Renal Replacement Therapy(CRRT)on the 28-day cumulative survival rate of patients with Sepsis-Induced Acute Kidney Injury(SI-AKI).[Methods]A total of 144 SI-AKI patients admitted to the ICU of our hospital were randomly divid-ed into an early CRRT group and a control group,with 72 patients in each group.Clinical data,treatment schemes,and the 28-day cumulative survival rates of the two groups were compared.The changes in inflam-matory and renal function indicators before and after treatment in both groups were compared as well.The im-pact of early CRRT on the 28-day cumulative survival rate was analyzed.[Results]Patients in the early CRRT group had a longer non-mechanical ventilation time than those in the control group(P＜0.05).Before treat-ment,there were no significant differences in any indicators between the two groups(P＞0.05).After treat-ment,all inflammatory indicators including procalcitonin(PCT),C-reactive protein(CRP),WBC,tumor nec-rosis factor-α(TNF-α),interleukin-6(IL-6),and renal function indicators such as serum creatinine(Scr),blood urea nitrogen(BUN),and Lactate,significantly decreased compared to before treatment(P＜0.05),and the reductions in PCT,CRP,IL-6,Scr,BUN in the early CRRT group were significantly greater than those in the control group(P＜0.05).Kaplan-Meier survival analysis indicated that the 28-day cumulative sur-vival rate of patients in the early CRRT group was significantly higher than that of the control group(P＜0.05).[Conclusion]Early initiation of CRRT can improve the 28-day cumulative survival rate of SI-AKI pa-tients and clinical outcomes.
NETL
NSTL
万方数据
