The Effect of Escitalopram on the Level of Inflammatory Factors and Endothelial Function in Pa-tients with Coronary Heart Disease Accompanied by Anxiety and Depression
[Objective]To investigate the effect of escitalopram on the levels of inflammatory factors and vascular en-dothelial function in patients with coronary heart disease accompanied by anxiety and depression.[Methods]A total of 112 patients with coronary heart disease accompanied by anxiety and depression admitted to two hospitals from July 2021 to July 2022 were selected and randomly divided into an observation group and a control group according to a random number table method,with 56 cases in each group.The control group was given conventional drug treatment,while the observa-tion group was treated with escitalopram on the basis of the control group.The vascular endothelial function[endothelin-1(ET-1),vascular endothelial growth factor(VEGF),nitric oxide(NO)],inflammatory factors[interleukin-2(IL-2),C-reactive protein(CRP),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)],neurotransmitters[brain-derived neuro-trophic factor(BDNF),norepinephrine(NE),serotonin(5-HT)],cognitive function[Loewenstein Cognitive Assessment Rating Scale(LOTCA)score],Hamilton Depression Rating Scale(HAMD)score,and Hamilton Anxiety Rating Scale(HAMA)score were compared before and after treatment between the two groups.[Results]After treatment,the levels of ET-1,TNF-α,IL-8,CRP,and IL-2 in the observation group were lower than those in the control group,while NO and VEGF were higher than those in the control group(P＜0.05).After treatment,the levels of BDNF,NE,and 5-HT in the observation group were higher than those in the control group(P＜0.05).After treatment,the LOTCA scores and total scores in the observation group were higher than those in the control group(P＜0.05).After treatment,the HAMD and HAMA scores in the observation group were lower than those in the control group(P＜0.05).[Conclusion]Escitalopram has significant effect on improving negative emotions in patients with coronary heart disease accompanied by anxiety and depression,which can reduce the inflammatory response and improve vascular endothelial function.
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